Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 1755-1759

  Lozo, Edith ^a   Riecke, Kai ^a   Schwabe, Rudolf ^a   Vormann, Jürgen ^a   Stahlmann, Ralf ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM; OFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE MINERAL; CHONDROPATHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; HISTOPATHOLOGY; IMMATURITY; MAGNESIUM BLOOD LEVEL; MAGNESIUM DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; ANTI-INFECTIVE AGENTS; CARTILAGE; CARTILAGE DISEASES; JOINTS; MAGNESIUM; MAGNESIUM DEFICIENCY; OFLOXACIN; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0036090547     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.1755-1759.2002     Document Type: Article

References (19)

1. Pharmacokinetics of oral and intravenous ofloxacin in children with multidrug-resistant typhoid fever
2. Determination of sparfloxacin in serum and urine by high-performance liquid chromatography
3. Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats
4. Morphological investigation of cavity formation in articular cartilage induced by ofloxacin in rats
5. Interaction of quinolones with metal cations in aqueous solution
6. Effect of magnesium complexation by fluoroquinolones on their anti-bacterial properties
7. Pharmacokinetics of ofloxacin after parenteral and oral administration
8. Absorption interactions with fluoroquinolones. 1995 update
9. Concentrations of ofloxacin in human bone and cartilage
10. Physicochemical properties of the fluoroquinolone antimicrobials. V. Effect of fluoroquinolone structure and pH on complexation of various fluoroquinolones with magnesium and calcium ions
11. Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet
12. Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations
13. Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical with quinolone-induced arthropathy
14. Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats
15. Toxicity of quinolones
16. Supplementation with magnesium and tocopherol diminishes quinolone-induced chondrotoxicity in immature rats
17. Safety overview. Toxicity, adverse effects, and interactions
18. Effects, of magnesium deficiency on magnesium and calcium content in bone and cartilage in developing rats in correlation to chondrotoxicity