Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats

Archives of Toxicology

Volumn 70, Issue 5, 1996, Pages 261-270

  Forster C ^a   Kociok, K ^a   Shakibaei, M ^a   Merker, H J ^a   Vormann, J ^a   Gunther T ^a   Stahlmann, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Immunohistochemistry; Integrin expression; Joint cartilage; Magnesium deficiency; Quinolone induced arthropathy

Indexed keywords

INTEGRIN; OFLOXACIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; HISTOLOGY; IMMATURITY; IMMUNOHISTOCHEMISTRY; MAGNESIUM DEFICIENCY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; CALCIUM; CARTILAGE, ARTICULAR; IMMUNOHISTOCHEMISTRY; INTEGRINS; MAGNESIUM DEFICIENCY; MICROSCOPY, ELECTRON; OFLOXACIN; RATS; RATS, WISTAR;

EID: 0030064176     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050272     Document Type: Article

References (45)

1. Barrach HJ, Grundmann K, Hinz, N, Felies A (1981) Comparison of the differentiation of muscle and connective tissue of mouse limb-buds in culture and in vivo: a morphological study by indirect immunofluorescence. In: Neubert D, Merker HJ (eds) Culture techniques. Walter de Gruyter Verlag, Berlin, pp 135-159
2. Bendele AM, Hulman JF, Harvey AK, Hrubey PS, Chandrasekhar S (1990) Passive role of articular chondrocytes in quinolone-induced arthropathy in guinea pigs. Toxicol Pathol 18: 304-312
3. Brennan MJ, Oldberg A, Hayman EG, Ruoslahti E (1983) Effect of a proteoglycan produced by rat tumor cells on their adhesion to fibronectin-collagen substrata. Cancer Res 43: 4302-4307
4. Brower TD, Hsu WY (1969) Normal articular cartilage. Clin Orthop Rel Res 64: 9-17
5. Burkhardt JE, Hill MA, Carlton WW, Kesterson JW (1990) Histologic and histochemical changes in articular cartilage of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 27: 162-170
6. Burkhardt JE, Hill MA, Turek JJ, Carlton WW (1992) Ultrastructural changes in articular cartilage of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 29: 230-238
7. Burkhardt JE, Hill MA, Lamar CH, Smith GN, Carlton WW (1993) Effects of difloxacin on the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Fundam Appl Toxicol 20: 257-263
8. Chandrasekhar S, Sorrentino JA, Millis AJT (1983) Interaction of fibronectin with collagen: age specific defect in the biological activity of human fibroblast fibronectin. Proc Natl Acad Sci USA 80: 4747-4751
9. Chapman JS, Georgopapadakou NH (1988) Routes of quinolone permeation in Escherichia coli. Antimicrob Agents Chemother 32: 438-442
10. Domagala JM (1994) Structure-activity and structure-side-effect relationship for the quinolone antibacterials. J Antimicrob Chemother 33: 685-706
11. 1-integrins in human cartilage and their role in chondrocyte adhesion to collagen and fibronectin. Exp Cell Res 207: 235-244
12. Dusemund B, Barrach HJ (1982) Double-antibody enzyme-linked immunosorbent microassay for quantifications of collagen types 1 and II. J Immunol Meth 50: 255-268
13. 1 integrins mediate chondrocyte interaction with type I collagen, type II collagen, and fibronectin. Exp Cell Res 205: 276-285
14. Förster C, Shakibaei M, Kociok K, Stürje H, Merker HJ, Vormann G, Günther T, Stahlmann R (1995) Quinolone-induced arthropathy is probably caused by magnesium deficiency in joint cartilage. Naunyn-Schmiedeberg's Arch Pharmacol 351: R 26 (Abstract #102)
15. Gough AW, Kasali OB, Siegler RE, Baragi V (1992) Quinolone arthropathy - acute toxicity to immature cartilage. Toxicol Pathol 20: 436-450
16. Hildebrandt H, Kempka G, Schlüter G, Schmidt M (1993) Chondrotoxicity of quinolones in vivo and in vitro. Arch Toxicol 67: 411-415
17. Howard LC, van Sickle DC, Deshmuckh K, Griffing DJ, Owen NV (1979) Cinoxacin induced arthropathy in juvenile beagle dogs. Toxicol Appl Pharmacol 48: Abstract 145
18. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25
19. Ingham B, Brentnall DW, Dale EA, MacFadzean JA (1977) Arthropathy induced by antibacterial fused N-alkyl-3-pyridone-carboxylic acids. Toxicol Lett 1: 21-26
20. Kato M, Onodera T (1988a) Morphological investigation of cavity formation in articular cartilage induced by ofloxacin in rats. Fundam Appl Toxicol 11: 110-119
21. Kato M, Onodera T (1988b) Morphological investigation of osteochondrosis induced by ofloxacin in rats. Fundam Appl Toxicol 11: 120-131
22. 3H]thymidine by articular cartilage cells in the rat. Toxicol Lett 44: 131-142
23. Knox P, Wells P (1979) Cell adhesion and proteoglycans. I. The effect of exogenous proteoglycans on the attachment of chick embryo fibroblasts to tissue culture plastic and collagen. J Cell Sci 40: 77-88
24. Landis WJ, Hodgen KJ (1990) Visualization of sulfur-containing components associated with proliferating chondrocytes from rat epiphyseal growth plate cartilage: possible proteoglycan and collagen co-migration. Anat Rec 226: 153-167
25. Loeser RF (1993) Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins. Arthr Rheum 36: 1103-1110
26. Loeser RF (1994) Modulation of integrin mediated attachment of chondrocytes to extracellular matrix proteins by cations, retinoic acid and transforming growth factor β. Exp Cell Res 211: 17-23
27. 1-integrin subunit. Exp Cell Res 212: 155-160
28. Lomaestro BM, Bailie GR (1991) Quinolone-cation interactions: a review. Ann Pharmacother 25: 1249-1258
29. Machida M, Kusajima H, Aijima H, Maeda A, Ishida R, Uchida H (1990) Toxicokinetic study of norfloxacin-induced arthropathy in juvenile animals. Toxicol Appl Pharmacol 105: 403-412
30. Maroudas A, Bullough P, Swansson SAV, Freeman MAR (1968) The permeability of articular cartilage. J Bone Joint Surg 50 B: 166-177
31. Marshall AJH, Piddock LJV (1993) Effect of cations and EDTA upon the activity of 18 quinolones, gentamicin, ceftazidime and polymixin against gram-negative and gram-positive bacteria. Drugs 45 [Suppl 3]: 150-151
32. Meissner A, Borner K, Koeppe, P (1990) Concentrations of ofloxacin in human bone and cartilage. J Antimicrob Chemother 26 (Suppl D): 69-74
33. 14C-DL-8280 in various animal species. Chemotherapy 32 [Suppl 1]: 1185-1202
34. Palu G, Valisena S, Ciarrochi G, Gatto B, Palumbo M (1992) Quinolone binding to DNA is mediated by magnesium ions. Proc Natl Acad Sci USA 89: 9671-9675
35. Rich AM, Pearlstein E, Weissmann G, Hoffstein ST (1981) Cartilage proteoglycans inhibit fibronectin-mediated adhesion. Nature 293: 224-226
36. Ruoslahti E (1988) Fibronectin and its veceptors, Annu Rev Biochem 57: 375-413
37. Ruoslahti E (1991) Integrins. J Clin Invest 87: 1-5
38. Salter DM, Hughes DE, Simpson R, Gardner DL (1992) Integrin expression by human articular chondrocytes. Br J Rheumatol 31: 231-234
39. Schlüter G (1986) Toxicology of ciprofloxacin. In: Neu HC, Weuta H (eds) First International Ciprofloxacin Workshop. Proc Excerpta Medica, pp 61-70
40. Shakibaei M, Abou-Rebyeh H, Merker HJ (1993) Integrins in ageing cartilage tissue in vitro. Histol Histopathol 8: 715-723
41. Stahlmann R, Merker HJ, Hinz N, Webb J, Heger W, Neubert D (1990) Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations. Arch Toxicol 64: 193-204
42. Stahlmann R, Förster C, Van Sickle D (1993) Quinolones in children. Are concerns over arthropathy justified? Drug Safety 9: 397-403
43. Stahlmann R, Förster C, Shakibaei M, Vormann J, Günther T, Merker HJ (1995) Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical with quinolone-induced arthropathy. Antimicrob Agents Chemother 39: 2013-2018
44. Tatsumi H, Senda H, Yatera S, Takemoto Y, Yamayoshi M, Ohnishi K (1978) Toxicological studies on pipemidic acid V. Effect on diarthrodial joints of experimental animals. J Toxicol Sci 3: 357-367
45. Woods VL Jr, Schreck PL, Gesink DS, Pacheco HO, Amiel D, Akeson WH, Lotz M (1994) Integrin expression by human articular chondrocytes. Arthr Rheum 37: 537-544