Gastric H-K-ATPase and acid-resistant surface proteins

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 6 45-6, 2002, Pages

  Thangarajah, Hariharan ^a   Wong, Aline ^a   Chow, Dar C ^a,b   Crothers Jr , James M ^a   Forte, John G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Gastric mucosal barrier; Glycoproteins; Protein stability

Indexed keywords

BICARBONATE; CHYMOTRYPSIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; PEPSIN A; PROTEINASE; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; DISULFIDE BOND; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RABBIT; STOMACH; STOMACH MUCUS; STOMACH PARIETAL CELL; STOMACH PH;

EID: 0036087235     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00399.2001     Document Type: Article

References (39)

1. Gastroduodenal mucosal protection
2. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity
3. Influence of the carbohydrate moiety on the proteolytic cleavage sites in ribonuclease B
4. +-ATPase
5. Physical stabilization of insulin by glycosylation
6. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits
7. +-ATPase activity is inhibited by reduction of disulfide bonds in β-subunit
8. Functional significance of the β-subunit for heterodimeric P-type ATPases
9. Dynamic regulation of gastric surface pH by luminal pH
10. The gastroduodenal mucus barrier and its role in protection against luminal pepsins: The effect of 16,16 dimethyl prostaglandin E2, carbopol-polyacrylate, sucralfate and bismuth subsalicylate
11. y) antigen is prominently expressed on the β-subunit of human gastric H,K-ATPase
12. Histochemical staining and characterization of glycoproteins in acid-secreting cells of frog stomach
13. Unfolding rates of globular proteins determined by kinetics of proteolysis
14. Effect of N-linked glycosylation on glycopeptide and glycoprotein structure
15. +-ATPase
16. Determination of three disulfide bonds and one free sulfhydryl in the β-subunit of (Na,K)-ATPase
17. +-ATPase in insect cells
18. Protein glycosylation. Structural and functional aspects
19. Structural organisation of human bile-salt-activated lipase probed by limited proteolysis and expression of a recombinant truncated variant
20. Functional protective role for mucin glycosylated repetitive domains
21. Role of mucus in mucosal protection through ethanol and pepsin damage models
22. Interaction of α- and β-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase β-subunit
23. +-ATPase
24. +-ATPase-containing membranes from the gastric oxyntic cell
25. Glycoforms modify the dynamic stability and functional activity of an enzyme
26. Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa
27. Characterization of lysosomal acid lipase by site-directed mutagenesis and heterologous expression
28. cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase
29. +-ATPase
30. Role of mucus in gastric mucosal protection
31. Intraluminal acid and gastric mucosal integrity: The importance of blood-borne bicarbonate
32. Mechanisms of gastric mucosal injury and protection
33. Structural interactions between α- and β-subunits of the gastric H,K-ATPase
34. The N-linked oligosaccharides of the β-subunit of rabbit gastric H,K-ATPase: Site localization and identification of novel structures
35. The β-subunit of the rabbit H,K-ATPase: A glycoprotein with all terminal lactosamine units capped with α-linked galactose residues
36. Influence of the carbohydrate moiety on the stability of glycoproteins
37. The structural role of sugars in glycoproteins
38. Thermodynamic and kinetic stabilities of hen-egg lysozyme and its chemically modified derivatives: Analysis of the transition state of the protein unfolding