Differential activation of human and guinea pig complement by pentameric and hexameric IgM

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1802-1810

  Bhandoola, Avinash ^a,d   Bosselut, Remy ^a   Yu, Qing ^a   Cowan, Michelle L ^a   Feigenbaum, Lionel ^b   Love, Paul E ^c   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Complement; Guinea pig; Human; IgM; Isoform

Indexed keywords

IMMUNOGLOBULIN M; TRINITROPHENYLHAPTEN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY STRUCTURE; ARTICLE; CELL FREE SYSTEM; CHIMERA; COMPLEMENT ACTIVATION; CONTROLLED STUDY; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNOASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; COMPLEMENT ACTIVATION; GUINEA PIGS; HUMANS; IMMUNOGLOBULIN M; MICE; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY;

EID: 0036086544     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1802::AID-IMMU1802>3.0.CO;2-C     Document Type: Article

References (33)

1. IgM - Molecular requirements for its assembly and function
2. Influence of the μ-chain C-terminal sequence on polymerization of immunoglobulin M
3. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins
4. Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain
5. On the structure of polymeric IgM
6. Inter-molecular disulfide bonding in IgM: Effects of replacing cysteine residues in the μ heavy chain
7. Polymer IgM assembly and secretion in lymphoid and nonlymphoid cell lines: Evidence that J chain is required for pentamer IgM synthesis
8. The biological effects of IgM hexamer formation
9. Structural and functional analysis of J chain-deficient IgM
10. Production of IgM hexamers by normal and autoimmune B cells: Implications for the physiological role of hexameric IgM
11. Complement fixation on cell surfaces by 19s and 7s antibodies
12. Hemolysin titration based on fixation of the activated first component of complement. Evidence that one molecule of hemolysin suffices to sensitize an erythrocyte
13. Measurement of macromolecular interactions between complement subcomponents C1q, C1r, C1s, and immunoglobulin IgM by sedimentation analysis using the analytical ultracentrifuge
14. J chain deficiency in human IgM monoclonal antibodies produced by Epstein-Barr virus-transformed B lymphocytes
15. Variable J-chain content in human IgM
16. Mechanism of IgM polymerization
17. Immunochemical studies on free and bound J chain of human IgA and IgM
18. The coming of age of the immunoglobulin J chain
19. Role of J chain in secretory immunoglobulin formation
20. Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B Cells
21. Lack of J chain inhibits the transport of gut lgA and abrogates the development of intestinal antitoxic protection
22. Activation of complement by immunoglobulin M is impaired by the substitution serine 406 asparagine in the immunoglobulin mu heavy chain
23. Complement activation by IgM: Evidence for the importance of the third constant domain of the μ heavy chain
24. Mapping of amino acid residues in the Cμ3 domain of mouse IgM important in macromolecular assembly and complement-dependent cytolysis
25. Structure and function of several anti-dansyl chimeric antibodies formed by domain interchanges between human IgM and mouse IgG2b
26. Domain-switched mouse IgM/IgG2b hybrids indicate individual roles for Cμ2, Cμ3, and Cμ4 domains in the regulation of the interaction of lgM with complement C1q
27. Activation of mouse complement by monoclonal antibodies
28. Deletions in immunoglobulin mu chains
29. Isolation of new nonsense and frameshift mutants in the Immunoglobulin μ heavy-chain gene of hybridoma cells
30. Homologous recombination in hybridoma cells: Dependence on time and fragment length
31. Production of functional chaemeric mouse/human antibody
32. Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells