Sequencing of the second exon of the MHC class II DQ6 alleles in patients with type 1 diabetes

Autoimmunity

Volumn 35, Issue 2, 2002, Pages 155-157

  Rayner, M L ^a   Kelly, M A ^a   Mijovic, C H ^a   Barnett, A H ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Disease protection; HLA DQ; MHC class II; Type 1 diabetes

Indexed keywords

DEOXYRIBONUCLEOTIDE; HLA DQ ANTIGEN; HLA DQ6 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLELE; ANTIGEN BINDING; ARTICLE; CLINICAL ARTICLE; EXON; FLUORESCENCE ANALYSIS; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENOTYPE; HLA TYPING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; NUCLEOTIDE SEQUENCE; PROTECTION; PROTEIN DOMAIN; SCHOOL CHILD; SEQUENCE ANALYSIS; WILD TYPE;

ADOLESCENT; ADULT; ALLELES; CHILD; DIABETES MELLITUS, TYPE 1; EXONS; HLA-DQ ANTIGENS; HUMANS; SEQUENCE ANALYSIS, DNA;

EID: 0036085285     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.1080/08916930290016637     Document Type: Article

References (9)

1. Analysis of HLA-DQ genotypes and susceptibility in insulin dependent diabetes mellitus
2. Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus
3. HLA-DQA1 and DQB1 alleles associated with genetic susceptibility to IDDM in a black population
4. Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin dependent) diabetes mellitus in a British Caucasian population
5. Molecular modelling of HLA-DQ suggests a mechanism of resistance in type 1 diabetes
6. Sequence analysis of the diabetes-protective human leukocyte antigen - DQB1*0602 allele in unaffected, islet cell antibody - Positive first degree relatives and in rare patients with type 1 diabetes
7. Phototyping comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)
8. Molecular basis for HLA-DQ association in IDDM
9. Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset