Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease

Infection and Immunity

Volumn 70, Issue 7, 2002, Pages 3944-3947

  Watanabe, Yukino ^a   Todome, Yuko ^a   Ohkuni, Hisashi ^a   Sakurada, Shinsaku ^a   Ishikawa, Toshio ^a   Yutsudo, Takashi ^a   Fischetti, Vincent A ^a   Zabriskie, John B ^a  

^a Medca Japan Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BACTERIAL TOXIN; CYSTEINE PROTEINASE; HISTAMINE; RECOMBINANT ENZYME; STREPTOCOCCAL PYROGENIC EXOTOXIN B; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXPRESSION VECTOR; HISTAMINE RELEASE; HUMAN; HUMAN CELL; MAST CELL; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION;

BACTERIAL PROTEINS; BASE SEQUENCE; CELL LINE; DNA, BACTERIAL; EXOTOXINS; HISTAMINE; HISTAMINE RELEASE; HUMANS; LIPOPOLYSACCHARIDES; MAST CELLS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; STREPTOCOCCUS PYOGENES;

EID: 0036084422     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.7.3944-3947.2002     Document Type: Article

References (20)

1. Cloning of the gene, speB, for streptococcal pyrogenic exotoxin type B in Escherichia coli
2. Activation of a 66-kilodalton human matrix metalloproteinase by Streptococcuspyogenes extracellular cysteine protease
3. Establishment of an immature mast cell line from a patient with mast cell leukemia
4. The rgg gene of Streptococcuspyogenes NZ131 positively influences extracellular SPE B production
5. Identification of Rgg-regulated exoproteins of Streptococcuspyogenes
6. Autocatalytic processing of streptococcal cysteine protease zymegen. Processing mechanism and characterization of the autoproteolytic cleavage sites
7. Isolation and characterization of erythrogenic toxins. V. Communications: Identity of erythrogenic exotoxin type B and streptococcal proteinase precursor
8. Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes
9. Nucleotide sequence of streptococcal pyogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor
10. Streptococcal cysteine protease releases kinins: A novel virulence mechanism
11. A simple plate assay for detection of group A Streptococcus proteinase
12. A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degradates vitronectin
13. Cleavage of interleukin 1β (IL-1β) precursor to produce active IL-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes
14. Role of streptococcal pyogenic exotoxin B in the mouse model of group A streptococcal infection
15. Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decrease mouse lethality of serotype M3 and M49 strain s
16. Genetic inactivation of an extracellular cysteine protease (Spe B) expressed by Streptococcus pyogenes decrease resistance to phagocytosis and dissemination to organs
17. Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1β convertase) alters proteolytic activity and ablates zymogen processing
18. Cysteine protease activity of streptococcal pyrogenic exotoxin B
19. Definition of the mitogenic factor (mf) as a novel streptococcal superantigen that is different from streptococcal pyrogenic exotoxins A, B, and C
20. Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci