Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 6 45-6, 2002, Pages

  Pratipanawatr, Thongchai ^a   Pratipanawatr, Wilailak ^a   Rosen, Clifford ^a   Berria, Rachele ^a   Bajaj, Mandeep ^a   Cusi, Kenneth ^a   Mandarino, Lawrence ^a   Kashyap, Sangeta ^a   Belfort, Renata ^a   DeFronzo, Ralph A ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Free fatty acid metabolism; Insulin resistance; Insulin like growth factor I; Type 2 diabetes mellitus

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; PALMITIC ACID; SOMATOMEDIN C; TRITIUM;

ADULT; ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FEMALE; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN INFUSION; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TURNOVER TIME;

EID: 0036081254     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00335.2001     Document Type: Article

References (51)

1. Studies of acute effects of insulin like growth factor I and II in human fat cells
2. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin: Dose-response relationships in healthy young and middle aged adults
3. Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating and fatal rat liver
4. Impaired insulin growth factor I-mediated stimulation of glucose incorporation into glycogen in vivo in the ob/ob mouse
5. Body growth, carcass composition, and endocrine changes in lambs chronically treated with recombinantly derived insulin-like growth factor-I
6. Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method
7. Recombinant human insulin-like growth factor I treatment for 1 wk improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance
8. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
9. Sensitivity of insulin secretion to feedback inhibition by hyperinsulinemia
10. Glucose clamp technique: A method for quantifying insulin secretion and resistance
11. IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM
12. Effects of recombinant human IGF-I on glucose and leucine kinetics in men
13. Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients
14. Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of non-insulin-dependent diabetes mellitus subjects
15. The effect of insulin on the distribution and disposition of glucose in man
16. Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans
17. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro
18. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
19. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults
20. A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting enhanced pulsatile growth hormone secretion in human
21. Acute effects off insulin-like growth factor I on glucose metabolism in the awake fasted rat: Comparison with insulin
22. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats
23. Simultaneous insulin-like growth factor I and insulin resistance in obese Zuker rats
24. Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice
25. Bioelectrical impedance analysis: A review of principles and applications
26. Effects of recombinant human insulin-like growth factor I and insulin on counter regulation during acute plasma glucose decrements in normal and type 2 (non-insulin-dependent) diabetic subjects
27. Comparison of the effects of recombinant human insulin-like growth factor-I and insulin on glucose and leucine kinetics in human
28. Molecular and cellular aspects of the insulin-like growth factor I receptor
29. Parallel insulin-like growth factor I and insulin resistance in muscles of rats fed a high fat diet
30. Characterization of insulin-like growth factor I receptor in skeletal muscles of normal and insulin resistant subjects
31. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor
32. Low dose recombinant human insulin-like growth factor-I fails to affect protein anabolism but inhibits islet cell secretion in humans
33. Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery
34. Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance
35. Acute effects of insulin like growth factor I and insulin on glucose metabolism in vivo
36. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase
37. Metabolic effects of IGF-I in diabetic rats
38. A comparison of the effects of IGF-I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers
39. 13C-nuclear magnetic resonance spectroscopy
40. A new correction factor for use in tracer estimations of plasma fatty acid oxidation
41. Indirect calorimetry: Methodological and interpretative problems
42. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
43. Mechanism of IGF-I stimulated glucose transport in human adipocytes: Demonstration of specific IGF-I receptors not involved in stimulation of glucose transport
44. Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
45. Influences of glucose loading and of injected insulin on hepatic glucose output
46. Effect of increasing doses of recombinant human insulin like growth factor I on glucose, lipid, and leucine metabolism in man
47. Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L 1 adipocytes
48. Insulin-like growth factor I receptors in adult rat liver: Characterization and in vivo regulation
49. Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus
50. Acute metabolic effects and half-lives of intravenously administered insulin-like growth factors I and II in normal and hypophysectomized rats
51. Effect of trypsin treatment of rat adipocytes on biological effect and binding of insulin and insulin-like growth factors