Persistent suppression of hepatic CYP2A1 expression and serum triiodothyronine levels by tamoxifen in intact female rats: Dose-response analysis and comparison with 4-hydroxytamoxifen, fulvestrant (ICI 182,780), and 17β-estradiol-3-benzoate

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 584-593

  Ickenstein, Ludger M ^a   Bandiera, Stelvio M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2A1; ESTRADIOL BENZOATE; FULVESTRANT; GROWTH HORMONE; LIOTHYRONINE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BODY WEIGHT; BREAST CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; ENZYME INHIBITION; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIOTHYRONINE BLOOD LEVEL; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THYROID HORMONE BLOOD LEVEL; UTERUS WEIGHT; WEIGHT REDUCTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BODY WEIGHT; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; ORGAN SIZE; OVARY; RATS; RATS, LONG-EVANS; STEROID HYDROXYLASES; TAMOXIFEN; TESTOSTERONE; THYROXINE; TIME FACTORS; TRIIODOTHYRONINE; UTERUS;

EID: 0036076618     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034744     Document Type: Article

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