Impact of tamoxifen on peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11, cytochrome P450 3A2, and steroid 5α-reductase

Biochemical Pharmacology

Volumn 51, Issue 3, 1996, Pages 357-368

  Chang, Thomas K H ^a   Chan, Maureen M Y ^a   Holsmer, Susan L ^a   Bandiera, Stelvio M ^a   Bellward, Gail D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

androgen imprinting; cytochrome P450; growth hormone; steroid 5 reductase; tamoxifen; testosterone

Indexed keywords

ANDROGEN; CYTOCHROME P450 ISOENZYME; LIVER ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; STEROID 5ALPHA REDUCTASE; TAMOXIFEN; TESTOSTERONE; TESTOSTERONE HYDROXYLASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; FEMALE; HORMONE METABOLISM; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PUBERTY; RAT; SEX DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030065018     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02191-4     Document Type: Article

References (63)

1. Russell DW and Wilson JD, Steroid 5α-reductase: Two genes/ two enzymes. Annu Rev Biochem 63: 25-61, 1994.
2. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K and Nebert DW, The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12: 1-51, 1993.
3. Waxman DJ and Chang TKH, Hormonal regulation of liver cytochrome P450 enzymes. In: Cytochrome P450: Structure, Mechanism, and Biochemistry (Ed. Ortiz de Montellano PR), 2nd Edn, pp. 391-417. Plenum Press, New York, 1995.
4. Legraverand C, Mode A, Wells T, Robinson I and Gustafsson JA, Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J 6: 711-718, 1992.
5. Thummel KE and Schenkman JB, Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat. Mol Pharmacol 37: 119-129, 1990.
6. Donahue BS, Skottner-Lundin A and Morgan ET, Growth hormone-dependent and -independent regulation of cytochrome P-450 isozyme expression in streptozotocin-diabetic rats. Endocrinology 128: 2065-2076, 1991.
7. Tannenbaum GS and Martin JB, Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98: 562-570, 1976.
8. Jansson JO, Eden S and Isaksson O, Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 6: 128-150, 1985.
9. Morgan ET, MacGeoch C and Gustafsson JA, Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16α-hydroxylase cytochrome P-450 apoprotein in the rat. J Biol Chem 260: 11895-11898, 1985.
10. Kato R, Yamazoe Y, Shimada M, Murayama N and Kamataki T, Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. J Biochem (Tokyo) 100: 895-902, 1986.
11. Yamazoe Y, Shimada M, Kamataki T and Kato R, Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes. Jpn J Pharmacol 42: 371-382, 1986.
12. Waxman DJ, Pampori NA, Ram PA, Agrawal AK and Shapiro BH, Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sci USA 88: 6868-6872, 1991.
13. Waxman DJ, Morrissey JJ and LeBlanc GA, Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (ILA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology 124: 2954-2966, 1989.
14. PB1 (IIC6) gene expression. Mol Pharmacol 38: 192-197, 1990.
15. Ram PA and Waxman DJ, Pretranslational control by thyroid hormone of rat liver steroid 5α-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem 265: 19223-19229, 1990.
16. MacGeoch C, Morgan ET, Halper JR and Gustafsson JA, Purification, characterization, and pituitary regulation of the sex-specific cytochrome P-450 15β-hydroxylase from liver microsomes of untreated female rats. J Biol Chem 259: 15433-15439, 1984.
17. Mode A and Norstedt G, Effects of gonadal steroid hormones on the hypothalamo-pituitary-liver axis in the control of sex differences in hepatic steroid metabolism in the rat. J Endocrinol 95: 181-187, 1982.
18. 4-steroid 5α-reductase, flavin-containing monoxygenase, and sex-specific cytochromes P-450. J Biol Chem 261: 10728-10735, 1986.
19. 15β apoprotein levels in rat liver. Endocrinology 117: 2085-2092, 1985.
20. Waxman DJ, LeBlanc GA, Morrissey JJ, Staunton J and Lapenson DP, Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J Biol Chem 263: 11396-11406, 1988.
21. Waxman DJ, Dannan GA and Guengerich FP, Regulation of rat hepatic cytochrome P-450: Age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry 24: 4409-4417, 1985.
22. Shimada M, Murayama N, Yamazoe Y, Kamataki T and Kato R, Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. Jpn J Pharmacol 45: 467-478, 1987.
23. Bandiera S, and Dworschak C, Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat. Arch Biochem Biophys 296: 286-295, 1992.
24. McClellan-Green PD, Linko P, Yeowell HN and Goldstein JA, Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. J Biol Chem 264: 18960-18965, 1989.
25. Ribeiro V and Lechner MC, Cloning and characterization of a novel CYP3A1 allelic variant: Analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone. Arch Biochem Biophys 293: 147-152, 1992.
26. Sundseth SS and Waxman DJ, Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid ω-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J Biol Chem 267: 3915-3921, 1992.
27. Kamataki T, Shimada M, Maeda K and Kato R, Pituitary regulation of sex-specific forms of cytochrome P-450 in liver microsomes of rats. Biochem Biophys Res Commun 130: 1247-1253, 1985.
28. Einarsson K, Gustafsson JA and Stenberg A, Neonatal imprinting of liver microsomal hydroxylation and reduction of steroids. J Biol Chem 248: 4987-4997, 1973.
29. Kamataki T, Maeda T, Shimada M, Nagai T and Kato R, Neonatal testosterone imprinting of hepatic microsomal drug metabolism and a male-specific form of cytochrome P-450 in the rat. J Biochem (Tokyo) 96: 1939-1942, 1984.
30. Pak RCK, Tsim KWK and Cheng CHK, Pubertal gonadal hormones in modulating the testosterone dependency of hepatic aryl hydrocarbon hydroxylase in female rats. Pharmacology 29: 121-127, 1984.
31. Pak RCK, Tsim KWK and Cheng CHK, The role of neonatal and pubertal gonadal hormones in regulating the sex dependence of the hepatic microsomal testosterone 5-reductase in the rat. J Endocrinol 106: 71-79, 1985.
32. Cadario BJ, Bellward GD, Bandiera S, Chang TKH, Ko WWW, Lemieux E and Pak RCK, Imprinting of hepatic microsomal cytochrome P-450 enzyme activities and cytochrome P-450IIC11 by peripubertal administration of testosterone in female rats. Mol Pharmacol 41: 981-988, 1992.
33. Jordan VC, The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 70(Suppl 4): 977-982, 1992.
34. Tannenbaum GS, Gurd W, LaPointe M and Pollak M, Tamoxifen attenuates pulsatile growth hormone secretion: Mediation in part by somatostatin. Endocrinology 130: 3395-3401, 1992.
35. Metzger DL and Kerrigan JR, Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: Evidence for a stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab 79: 513-518, 1994.
36. Jordan VC, Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. Eur J Cancer 12: 419-424, 1976.
37. Lu AYH and Levin W, Partial purification of cytochrome P-450 and P-448 from rat liver microsomes. Biochem Biophys Res Commun 46: 1334-1339, 1972.
38. 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. J Biol Chem 258: 8839-8847, 1983.
39. Chang T, Levine M, Bandiera SM and Bellward GD, Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine. J Pharmacol Exp Ther 260: 1441-1449, 1992.
40. Chang TKH and Waxman DJ, Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5α-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard. Cancer Res 53: 2490-2497, 1993.
41. Omura T and Sato R, The carbon monoxide binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem 239: 2379-2385, 1964.
42. Strobel HW and Dignam JD, Purification and properties of NADPH-cytochrome P-450 reductase. Methods Enzymol 52: 89-96, 1978.
43. Cooper KO, Reik LM, Jayyosi Z, Bandiera S, Kelley M, Ryan DE, Daniel R, McCluskey SA, Levin W, and Thomas PE, Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys 301: 345-354, 1993.
44. Laemmli UK, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
45. Thomas PE, Reik LM, Ryan DE and Levin W, Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes. J Biol Chem 259: 3890-3899, 1984.
46. Waxman DJ, Lapenson DP, Park SS, Attisano C and Gelboin HV, Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations. Mol Pharmacol 32: 615-624, 1987.
47. Levin W, Thomas PE, Ryan DE and Wood AW, Isozyme specificity of testosterone 7α-hydroxylation in rat hepatic microsomes: Is cytochrome P-450a the sole catalyst? Arch Biochem Biophys 258: 630-635, 1987.
48. Arlotto MP and Parkinson A, Identification of cytochrome P450a (P450IIA1) as the principal testosterone 7α-hydroxylase in rat liver microsomes and its regulation by thyroid hormones. Arch Biochem Biophys 270: 458-471, 1989.
49. Waxman DJ, Morrissey JJ and LeBlanc GA, Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: Pituitary control of hepatic NADPH cytochrome P-450 reductase. Mol Pharmacol 35: 519-525, 1989.
50. Miwa GT, West SB and Lu AYH, Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes. J Biol Chem 253: 1921-1929, 1978.
51. Kaminsky LS and Guengerich FP, Cytochrome P-450 isozyme/ isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. Eur J Biochem 149: 479-489, 1985.
52. Bullock P, Gemzik B, Johnson D, Thomas P and Parkinson A, Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5a-reductase. Proc Natl Acad Sci USA 88: 5227-5231, 1991.
53. Charlton HM, Clark RG, Robinson ICAF, Portergoff AE, Cox BS, Bugnon C and Bloch BA, Growth hormone-deficient dwarfism in the rat: A new mutation. J Endocrinol 119: 51-58, 1988.
54. Shapiro BH, MacLeod JN, Pampori NA, Morrissey JJ, Lapenson DP and Waxman DJ, Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450. Endocrinology 125: 2935-2944, 1989.
55. Waxman DJ, Morrissey JJ, MacLeod JN, and Shapiro BH, Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5α-reductase. Endocrinology 126: 712-720, 1990.
56. Millard WJ, Martin JB Jr, Audet J, Sagar SM and Martin JB, Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor. Endocrinology 110: 540-550, 1982.
57. Sundseth SS, Alberta JA and Waxman DJ, Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J Biol Chem 267: 3907-3914, 1992.
58. Legraverend C, Mode A, Westin S, Strom A, Eguchi H, Zaphiropoulos PG and Gustafsson JA, Transcriptional regulation of rat P-450 ZC gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol Endocrinol 6: 259-266, 1992.
59. Ryan DE and Levin W, Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol Ther 45: 153-239, 1990.
60. Eden S, Age-and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105: 555-560, 1979.
61. Jansson JO and Frohman LA, Differential effects of neonatal and adult androgen exposure on the growth hormone secretory pattern in male rats. Endocrinology 120: 1551-1557, 1987.
62. Painson J-C, Thorner MO, Krieg RJ and Tannenbaum GS, Short term adult exposure to estradiol feminizes the male pattern of spontaneous and growth hormone-releasing factor-stimulated growth hormone secretion in the rat. Endocrinology 130: 511-519, 1992.
63. 3H]estradiol in GRF neurons. Endocrinology 127: 344-349, 1990.