Roles of p38 mitogen-activated protein kinase, NF-κB, and protein kinase C in proinflammatory cytokine mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila

Infection and Immunity

Volumn 70, Issue 8, 2002, Pages 4132-4141

  Kim, Hyung Yong ^a   Rikihisa, Yasuko ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANAPLASMA; ANAPLASMA PHAGOCYTOPHILA; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; INTERNALIZATION; LEUKOCYTE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

ANAPLASMA; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; EHRLICHIOSIS; ENZYME ACTIVATION; GENE EXPRESSION; HL-60 CELLS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NEUTROPHILS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036071945     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.8.4132-4141.2002     Document Type: Article

References (52)

1. Use and specificity of genistein as inhibitor of protein-tyrosine kinases
2. Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis
3. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
4. Clinical and laboratory characteristics of human granulocytic ehrlichiosis
5. Serologic evidence of human granulocytic ehrlichiosis in Norway
6. Mechanism of cycloheximide inhibition of protein synthesis in a cell-free system prepared from rat liver
7. Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1
8. Identification of a granulocytotrophic Ehrlichia species as the etiological agent of human disease
9. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase N-[2-(p-bromocinnamylamino) ethyl] 5-isoquinolinesulfonamide(H-89), of PC12D pheochromocytoma cells
10. Cellular activation mechanisms in septic shock
11. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; description of six new species combinations; and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila
12. The role of protein kinase C and calcium in induction of human polymorphonu clear leukocyte IL-1β gene expression by GM-CSF
13. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes
14. Intracellular parasitism by human granuolocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1
15. Isoquinoline-sulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
16. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation
17. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
18. Inhibitors of translation
19. Expression of interleukin-1β, tumor necrosis factor alpha, and interleukin-6 in human peripheral blood leukocytes exposed to viable human granulocytic ehrlichiosis agent or recombinant major surface protein P44
20. The agent of human granulocytic ehrlichiosis induces the production of myelosuppressing chemokines without induction of proinflammatory cytokines
21. Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
22. Activation of the protein kinase A increases the DNA-binding and transcriptional activity of c-Rel in T cells
23. Immunoserologic evidence of human granulocytic ehrlichiosis in Danish patients with Lyme neuroborreliosis
24. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
25. Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections
26. Evidence for participation of transglutaminase in receptor-mediated endocytosis
27. Activation of interleukin-6 gene expression through the NF-κB transcription factor
28. Rapid activation of protein tyrosine kinase and phospholipase C-γ2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
29. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
30. Clinical and serological follow-up of patients with human granulocytic ehrlichiosis in Slovenia
31. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
32. Activation of the NF-κB pathway by inflammatory stimuli in human neutrophils
33. The human ehrlichioses in the United States
34. Human granulocytic ehrlichiosis agent inhibits superoxide anion generation by human neutrophils
35. Effects of Anaplasma phagocytophila on NADPH oxidase components in human neutrophils and HL-60 cells
36. Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
37. The ubiquitin-proteasome pathway is required for processing the NF-κBI precursor protein and the activation of NF-κB
38. Human disease in Europe caused by a granulocytic Ehrlichia species
39. Signal transduction pathways involved in the activation of NF-κB, AP-1, and c-fos by Mycoplasma fermentans membrane lipoproteins in macrophages
40. The regulation of human tumor necrosis factor α promoter region in macrophages, T cells, and B cell lines
41. New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells
42. Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York State
43. Inhibition of infection of macrophages with Ehrlichia risticü by cytochalasins, monodansylcadaverine, and taxol
44. 2+ and calmodulin in ehrlichial infection in macrophages
45. Regulation of NF-κB activation by MAP kinase cascades
46. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages
47. LPS-induced NF-κB activation and TNF-α release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent
48. 2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells
49. Intracellular infection by the human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis
50. Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin-1 beta and NF-κB activation, but not NF-κB nuclear translocation
51. Cloning and expression of 44-kilodalton major outer membrane protein gene of the human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis
52. The interaction of phenylalkylamine calcium channel blocked with the 1,4-dihydropyridine binding site