From cytogenetics to cytogenomics of thyroid tumors;De la cytogénétique à la cytogénomique des tumeurs de la thyroïde

Bulletin du Cancer

Volumn 89, Issue 6, 2002, Pages 588-592

  Perissel, Bernard ^a   Bernheim, Alain ^a   Couturier, Jérôme ^a   Fouilhoux, Geneviève ^a   Vago, Philippe ^a  

^a Dept de Santé Publique   (France)

Author keywords

Adenoma; Carcinoma; Cytogenetics; Fusion genes; Thyroid

Indexed keywords

GENE PRODUCT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

BENIGN TUMOR; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; COMPARATIVE STUDY; CYTOGENETICS; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR CARCINOMA; FUSION GENE; GENE LOCUS; GENOMICS; GOITER; HUMAN; PAPILLARY CARCINOMA; PROGNOSIS; REVIEW; SIPPLE SYNDROME; THYROID CANCER; TRISOMY 12; TRISOMY 16; TRISOMY 7;

ADENOMA; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY; CHROMOSOME ABERRATIONS; HUMANS; HYPERPLASIA; THYROID GLAND; THYROID NEOPLASMS;

EID: 0036071079     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Histological typing of thyroid tumors
2. Cytogenetic investigations of 340 thyroid hyperplasias and adenomas revealing correlations between cytogenetic findings and histology
3. Cytogenetic abnormalities associated with endocrine neoplasia
4. A characteristic sequence of trisomies starting with trisomy 7 in benign thyroid tumors
5. Numerical aberrations, including trisomy 22 as the sole anomaly, are recurrent in thyroid adenomas
6. Comparison of benign and malignant follicular thyroid tumors by comparative genomic hybridization
7. Frequent chromosomal DNA unbalance in thyroid oncocytic (Hurthle cell) neoplasms detected by comparative genomic hybridization
8. Involvement of 19q13 in follicular thyroid adenoma
9. A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors
10. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
11. Follicular tyroid carcinoma: Chromosome analysis of 19 cases
12. Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers
13. Frequent loss of heterozygoty on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma
14. DNA copy number changes in thyroid carcinoma
15. Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways
16. PAX 8-PPARγ 1 fusion oncogen in human thyroid carcinoma
17. Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas
18. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas
19. Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma
20. Translocation t(10;14)(q11.2;q22.1) fusing the kinetin to the RET gene creates a novel rearrangged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma
21. Molecular basis of hurthle cell papillary thyroid carcinoma
22. Hypodiploid, pseudodiploid, and normal karyotypes prevail in cytogenetic studies of medullary carcinomas of the thyroid and metastatic tissues
23. RET proto-oncogene in the development of human cancer
24. Cytogenetical observations in five anaplastic thyroid carcinomas
25. Frequent occurrence of cytogenetic abnormalities in sporadic non medullary thyroid carcinoma
26. Cytogenetic and fluorescence in situ hybridization studies in a case of anaplastic thyroid carcinoma
27. Allelotyping of anaplastic thyroid carcinoma: Frequent allelic losses on 1q, 9p, 11, 17, 19p, and 22q