Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer

Journal of the National Cancer Institute

Volumn 88, Issue 18, 1996, Pages 1317-1319

  Han, Hye Jung ^a   Yuan, Ying ^a   Ku, Ja Lok ^a   Oh, Jae Hwan ^a   Won, Yong Jin ^a   Kang, Koo Jeong ^a   Kim, Kwang Yun ^a   Kim, Sung ^a   Kim, Cheong Yong ^a   Kim, Jin Pok ^a   Oh, Nahm Gun ^a   Lee, Kee Hyung ^a   Choe, Kuk Jin ^a   Nakamura, Yusuke ^b   Park, Jae Gahb ^a  

^a Seoul National University College of Medicine   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER FAMILY; CANCER GENETICS; CANCER REGISTRY; CLINICAL ARTICLE; COLORECTAL CANCER; FAMILIAL CANCER; GENE MUTATION; HUMAN; KOREA;

EID: 9544241423     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/88.18.1317     Document Type: Article

References (20)

1. Vasen HF. What is hereditary nonpolyposis colorectal cancer (HNPCC)? Anticancer Res 1994;14:1613-6.
2. Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer [published erratum appears in Cell 1994;77:167]. Cell 1993;75:1027-38.
3. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993;75:1215-25.
4. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994;368:258-61.
5. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, et al. Mutation of a mutL homolog in hereditary colon cancer [see comment citation in Medline]. Science 1994;263:1625-9.
6. Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994;371:75-80.
7. Han HJ, Yanagisawa A, Kato Y, Park JG, Nakamura Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 1993;53:5087-9.
8. Loeb LA, Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 1994;54:5059-63.
9. Aaltonen LA, Peltomaki P, Mecklin JP, Jarvinen H, Jass JR, Green JS, et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994;54:1645-8.
10. Liu B, Parsons RE, Hamilton SR, Petersen GM, Lynch HT, Watson P, et al. hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 1994; 54:4590-4.
11. Nystrom-Lahti M, Parsons R, Sistonen P, Pylkkanen L, Aaltonen LA, Leach FS, et al. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am J Hum Genet 1994;55:659-65.
12. Lindblom A, Tannergard P, Werelius B, Nordenskjold M. Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nat Genet 1993;5:279-82.
13. Man HJ, Maruyama M, Baba S, Park JG, Nakamura Y. Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Hum Mol Genet 1995;4:237-42.
14. Vasen HF, Mecklin JP, Khan PM, Lynch HT. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991;34:424-5.
15. Blin N, Stafford DM. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res, 1976; 3:2303-8.
16. Nystrom-Lahti M, Kristo P, Nicolaides NC, Chang SY, Aaltonen LA, Moisio AL, et al. Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med 1995;1:1203-6.
17. Wijnen J, Khan PM, Vasen H, Menko F, van der Klift H, van den Broek M, et al. Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16, Am J Hum Genet 1996;58:300-7.
18. Miyaki M, Konishi M, Muraoka M, Kikuchi-Yanoshita R, Tanaka K, Iwama T, et al. Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients. J Mol Med 1995;73:515-20.
19. Fishel R, Kolodner RD. Identification of mismatch repair genes and their role in the development of cancer. Cur Opin Genet Dev 1995;5:382-95.
20. Nystrom-Lahti M, Moisio AL, Hofstra RM, Osinga J, Mecklin JP, Jarvinen HJ, et al. DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet 1996;5:763-9.