Thiopurine S-methyltransferase activity in Japanese subjects: Metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes

Clinica Chimica Acta

Volumn 323, Issue 1-2, 2002, Pages 147-150

  Nishida, Akihito ^a   Kubota, Takahiro ^a   Yamada, Yasuhiko ^a   Higashi, Katsumi ^a   Kitamura, Kiyoshi ^a   Nakahara, Kazuhiko ^a   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Genetic polymorphism; HPLC; Japanese; Phenotyping; Red blood cell; Thiopurine S methyltransferase

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; MERCAPTOPURINE; METHYLMERCAPTOPURINE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CELL LYSATE; CLINICAL ARTICLE; CODOMINANCE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ERYTHROCYTE; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METHYLATION; NORMAL HUMAN; PRIORITY JOURNAL; STANDARD;

6-MERCAPTOPURINE; ASIAN CONTINENTAL ANCESTRY GROUP; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENOTYPE; HUMANS; METHYLATION; METHYLTRANSFERASES; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY;

EID: 0036064904     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(02)00184-5     Document Type: Article

References (13)

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3. Human erythrocyte thiopurine methytransferase: Radiochemical microassay and biochemical properties
4. Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and inheritance of TPMT*3C in the family of a propositus
5. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
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10. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
11. Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
12. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
13. Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathiopurine and mercaptopurine intolerance