A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 445-451

  Eguchi, Takanori ^a   Kubota, Satoshi ^a   Kondo, Seiji ^a   Kuboki, Takuo ^a   Yatani, Hirofumi ^a   Takigawa, Masaharu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chondrocyte; Connective tissue growth factor; Gene expression; Transcription factor; Transforming growth factor

Indexed keywords

CELL EXTRACT; CONNECTIVE TISSUE GROWTH FACTOR; DNA; LUCIFERASE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING AFFINITY; CARTILAGE CELL; CELL NUCLEUS; CELL SPECIFICITY; CONTROLLED STUDY; DELETION MUTANT; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME ASSAY; FIBROBLAST; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CHONDROCYTES; DNA; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS;

EID: 0036062468     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00700-3     Document Type: Article

References (23)

1. The modular architecture of a new family of growth regulators related to connective tissue growth factor
2. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
3. The CCN family of angiogenic regulators: The integrin connection
4. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions
5. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
6. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
7. Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA
8. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture
9. Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro
10. Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
11. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
12. Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8
13. Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes
14. Establishment from a human chondrosarcoma of a new immortal cell line with high tumorigenicity in vivo, which is able to form proteoglycan-rich cartilage-like nodules and to respond to insulin in vitro
15. Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis
16. CTGF SMADs: Maintenance of scleroderma phenotype is independent of SMAD signalling
17. TGF-beta signaling by Smad proteins
18. The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts
19. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
20. Oligonucleotides as transcription factor decoys
21. Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides