Fiber shaft extension in combination with HI loop ligands augments infectivity for CAR-negative tumor targets but does not enchance hepatotropism in vivo

Gene Therapy

Volumn 9, Issue 16, 2002, Pages 1101-1108

  Seki, T ^a   Dmitriev, I ^a   Suzuki, K ^a   Kashentseva, E ^a   Takayama, K ^a   Rots, M ^a   Uil, T ^a   Wu, H ^a   Wang, M ^a   Curiel, D T ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Adenovirus; CAR; Fiber shaft; Gene therapy; Tumor

Indexed keywords

LIGAND; VIRUS RECEPTOR; VIRUS VECTOR;

ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEROTYPE; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTIVITY; VIRUS VIRULENCE;

ADENOVIRUSES, HUMAN; ANIMALS; CAPSID; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIGANDS; LIVER; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; RECEPTORS, VIRUS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; COXSACKIEVIRUS; HUMAN ADENOVIRUS;

EID: 0036054322     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301815     Document Type: Article

References (30)

1. Update on adenovirus and its vectors
2. Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection
3. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer
4. Targeted gene delivery by tropism-modified adenoviral vectors
5. Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor
6. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob
7. Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types
8. Expression of a foreign epitope on the surface of the adenovirus hexon
9. Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs
10. Adenovirus type 5 and 7 capsid chimera: Fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes
11. Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration
12. Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir therapy of hepatocellular carcinoma: The woodchuck animal model
13. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
14. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
15. Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector
16. Blood clearance rates of adenovirus type 5 in mice
17. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells
18. Artificial extension of the adenovirus fiber shaft inhibits infectivity in coxsackievirus and adenovirus receptor-positive cell lines
19. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
20. v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers
21. Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer
22. Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base
23. Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
24. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
25. Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo
26. A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein
27. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism
28. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12
29. Oligomerization of recombinant penton base of adenovirus type 2 and its assembly with fiber in baculovirus-infected cells
30. Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomein