Septic shock and multiple organ failure after hematopoietic stem cell transplantation: Treatment with recombinant human activated protein C

Bone Marrow Transplantation

Volumn 30, Issue 2, 2002, Pages 131-134

  Pastores, S M ^a   Papadopoulos, E ^a   van den Brink, M ^a   Alicea, M ^a   Halpern, N A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Drotrecogin alfa (activated); Hematopoietic stem cell transplantation; Multiple organ failure; Recombinant human activated protein C; Septic shock; Severe sepsis

Indexed keywords

ACICLOVIR; ACTIVATED PROTEIN C; ALEMTUZUMAB; AMPHOTERICIN B LIPID COMPLEX; ANTIBIOTIC AGENT; AZITHROMYCIN; CALCIUM CARBONATE; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DOXORUBICIN; DROTRECOGIN; FLUCONAZOLE; FLUDARABINE; FOLIC ACID; GANCICLOVIR; IMMUNOGLOBULIN; LANSOPRAZOLE; LORAZEPAM; MELPHALAN; METRONIDAZOLE; MULTIVITAMIN; PIPERACILLIN PLUS TAZOBACTAM; PREDNISONE; THIOTEPA; VANCOMYCIN; VINCRISTINE; PROTEIN C; RECOMBINANT PROTEIN;

ABSCESS; ADULT; ARTICLE; BLOOD CLOTTING; CANCER RECURRENCE; CASE REPORT; CHRONIC MYELOID LEUKEMIA; COMORBIDITY; DISEASE SEVERITY; DRUG APPROVAL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FEMALE; FOOD AND DRUG ADMINISTRATION; GRAFT FAILURE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIGH RISK PATIENT; HUMAN; INFECTION; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL; PREDICTION; PRIORITY JOURNAL; SEPTIC SHOCK; TREATMENT OUTCOME; CHRONIC LYMPHATIC LEUKEMIA;

ADULT; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MULTIPLE ORGAN FAILURE; PROTEIN C; RECOMBINANT PROTEINS; SHOCK, SEPTIC; TREATMENT OUTCOME;

EID: 0036053453     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703618     Document Type: Article

References (21)

1. Bone marrow transplantation
2. Critical care of the hematopoietic stem cell patient
3. Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation
4. Outcome of bone marrow transplantation patients requiring mechanical ventilation
5. Admission of bone marrow transplant recipients to the intensive care unit: Outcome, survival and prognostic factors
6. Sepsis: A new hypothesis for pathogenesis of the disease process
7. Regulation of blood coagulation
8. Recombinant human activated protein C: A system modulator of vascular function for treatment of severe sepsis
9. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications
10. Low levels of protein C are associated with poor outcome in severe sepsis
11. APACHE II: A severity of disease classification system
12. Multicenter outcome study of cancer patients admitted to the intensive care unit: A probability of mortality model
13. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis
14. Efficacy and safety of recombinant human activated protein C for severe sepsis
15. Multiple organ dysfunction syndrome in bone marrow transplantation
16. Naturally occurring anticoagulants and bone marrow transplantation: Plasma protein C predicts the development of veno-occlusive disease of the liver
17. Organ dysfunction following stem cell transplantation: Relationship to plasma cytokine concentrations
18. Treating patients with severe sepsis
19. The sepsis syndrome in a Dutch university hospital: Clinical observations
20. Effects of ibuprofen on the physiology and survival of patients with sepsis