Enforced expression of HOX11 is associated with an immature phenotype in J2E erythroid cells

British Journal of Haematology

Volumn 118, Issue 3, 2002, Pages 909-917

  Greene, Wayne K ^a,b   Ford, Jette ^a   Dixon, Darcelle ^b   Tilbrook, Peta A ^c,d   Watt, Paul M ^a   Klinken, S Peter ^c,d   Kees, Ursula R ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b MURDOCH UNIVERSITY   (Australia)

^c ROYAL PERTH HOSPITAL   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Differentiation; Erythroblast; Homeodomain oncoprotein; HOX11; Immature phenotype

Indexed keywords

COMPLEMENTARY DNA; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GLOBIN; HEMOGLOBIN; ONCOPROTEIN; PROTEIN HOX11; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CLONING; CELL DIFFERENTIATION; CELL LEVEL; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; GENE OVEREXPRESSION; HEMATOPOIETIC STEM CELL; HEMOGLOBIN SYNTHESIS; LEUKEMIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; DNA, COMPLEMENTARY; ERYTHROID PROGENITOR CELLS; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; NEOPLASM PROTEINS; ONCOGENE PROTEINS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036040599     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03704.x     Document Type: Article

References (54)

1. Erythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by chemical induction
2. Diaminofluorene is more sensitive than benzidine for detecting hemoglobin in erythropoietin responsive J2E cells
3. Adhesive properties of human erythroblastic precursor cells
4. Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors
5. The Hox11 gene is essential for cell survival during spleen development
6. Characterization of HOX gene expression during myelopoiesis: Role of HOXA5 in lineage commitment and maturation
7. Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation
8. Drosophila Hox complex downstream targets and the function of homeotic genes
9. The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH3T3 cells but represses its expression in mouse spleen development
10. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia
11. The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors
12. Transforming function of the HOX11/TCL3 homeobox gene
13. A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice
14. The role of chromosome translocations in T cell acute leukemia
15. Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation
16. Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors
17. Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells
18. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint
19. PER-117: A new human ALL cell line with an immature thymic phenotype
20. Overexpression of HOX11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential
21. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24
22. In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin
23. Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen
24. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages
25. Homeobox genes in normal hematopoiesis and leukemia
26. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
27. Dysregulation of HOX11 by chromosome translocations in T-cell acute lymphoblastic leukemia: A paradigm for homeobox gene involvement in human cancer
28. Oncogenic transcription factors in the human acute leukemias
29. Coordinate regulation of HOX genes in human hematopoietic cells
30. Effects of HOX homeobox genes in blood cell differentiation
31. Optimal activation of an endogenous gene by HOX11 requires the NH2-terminal 50 amino acids
32. Erythroid-restricted expression of homeobox genes of the human HOX 2 locus
33. pEF-BOS, a powerful mammalian expression vector
34. Identification of homeobox genes expressed in human haemopoietic progenitor cells
35. Expression and function of c-Kit in hemopoietic progenitor cells
36. Loss of adhesion of murine erythroleukemia cells to fibronectin during erythroid differentiation
37. A model for extradenticle function as a switch that changes HOX proteins from repressors to activators
38. All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-Kit+Sca-1(+)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors
39. All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells
40. Hox11 controls the genesis of the spleen
41. Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases
42. HOX11 expression in pediatric acute lymphoblastic leukemia is associated with T-cell phenotype
43. Expression of homeobox genes in human erythroleukemia cells
44. Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines
45. The optimal binding sequence of the Hox11 protein contains a predicted recognition core motif
46. Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties
47. Disrupted signaling in a mutant J2E cell line that shows enhanced viability, but does not proliferate or differentiate, with erythropoietin
48. Changes in c-Kit expression and effects of SCF during differentiation of human erythroid progenitor cells
49. Lineage and stage specific expression of HOX 1 genes in the human hematopoietic system
50. Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes
51. Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism
52. Three distinct domains in the HOX11 homeobox oncoprotein are required for optimal transactivation
53. HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization
54. The t(10;14) (q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24