Psoriasis is mediated by a cutaneous defect triggered by activated immunocytes: Induction of psoriasis by cells with natural killer receptors

Journal of Investigative Dermatology

Volumn 119, Issue 2, 2002, Pages 384-391

  Gilhar, Amos ^a   Ullmann, Yehuda ^a   Kerner, Hedviga ^a   Assy, Bedia ^a   Shalaginov, Raya ^a   Serafimovich, Sima ^a   Kalish, Richard S ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Human; Natural killer lymphocytes; Psoriasis; SCID mice; Skin

Indexed keywords

CD1 ANTIGEN; CELL RECEPTOR; CYTOKERATIN; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; NATURAL KILLER CELL RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATITIS; EPIDERMIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; LYMPHOCYTE; LYMPHOID CELL LINE; MONONUCLEAR CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SCID MOUSE; SKIN DEFECT; SKIN EDEMA; SKIN GRAFT; SKIN MANIFESTATION; SKINFOLD THICKNESS;

EID: 0036038079     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01812.x     Document Type: Article

References (40)

1. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alfa, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
2. Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction
3. The genetics of psoriasis: A complex disorder of the skin and immune system
4. Pulling the trigger on psoriasis
5. Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model
6. Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells
7. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
8. A peculiar sequence motif in the alpha-1-domain of the HLA-C molecule in psoriasis
9. + T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic plaque psoriasis
10. Cell-mediated immunity in experimental murine dermatophytosis. II. Adoptive transfer of immunity to dermatophyte infection by lymphoid cells from donors with acute or chronic infections
11. A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer
12. Psoriasis induced at the injection site of recombinant gamma interferon
13. Response of grafts from patients with alopecia areata transplanted onto nude mice, to administration of gamma-interferon
14. In vitro destruction of melanocytes by the IgG fraction of serum from patients with vitiligo
15. T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice
16. Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques
17. Response of psoriasis to a lymphocyte-selective toxin (DAB389 IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis
18. Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis
19. Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: Results of a pilot, multicenter, multiple-dose, placebo-controlled study
20. The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats
21. Nonspecifically activated human peripheral blood mononuclear cells are cytotoxic for human keratinocytes in vitro
22. Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4+2H4- inducer cells
23. Involved and uninvolved skin from psoriatic subjects: Are they equally diseased? Assessment by skin transplanted to congenitally athymic (nude) mice
24. Human dermatophyte-responsive T-cell lines recognize cross reactive antigens with mannose-rich glycoproteins
25. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers
26. Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene
27. Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: Human skin model of psoriasis
28. Is psoriasis a T-cell disease? Controversies in experimental dermatology
29. Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: Detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161
30. Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system
31. Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines
32. Distribution of interferon-gamma receptors in normal and psoriatic skin
33. Detection of the interferon-gamma-induced protein 10 in psoriasiform dermatitis of acquired immunodeficiency syndrome
34. + subsets
35. Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells
36. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
37. IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production
38. A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes
39. Dermal injection of immunocytes induces psoriasis
40. Expression of interleukin-12 is increased in psoriatic skin