Cyclins in breast cancer: Too much of a good thing

Breast Cancer Research

Volumn 4, Issue 4, 2002, Pages 145-147

  Enders, Greg H ^a  

^a Penn/GI Division   (United States)

Author keywords

Breast cancer; Cdc4; Cyclin; Proteolysis

Indexed keywords

CYCLIN E; PROTEIN CDC42; UBIQUITIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARCINOGENESIS; CELL DIVISION; CONTROLLED STUDY; DROSOPHILA; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY;

BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CYCLINS; F-BOX PROTEINS; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES;

EID: 0036037087     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr439     Document Type: Article

References (25)

1. Cancer Cell Cycles
2. Redundant cyclin overexpression and gene amplification in breast cancer cells
3. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
4. Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors
5. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
6. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
7. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
8. Specific protection against breast cancers by cyclin D1 ablation
9. Deregulated cyclin E induces chromosome instability
10. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E
11. Cyclins as markers of tumor proliferation: Immunocytochemical studies in breast cancer
12. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
13. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
14. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
15. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
16. Regulation of the G1 to S transition by the ubiquitin pathway
17. Proteolysis and the cell cycle: With this RING I do thee destroy
18. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
19. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
20. A family of mammalian F-box proteins
21. Identification of a family of human F-box proteins
22. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
23. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
24. S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant negative mutant in human cells
25. CDK inhibition and cancer therapy