Interferon-γ, a strong suppressor of cell proliferation, induces upregulation of keratin K6, one of the inflammatory- and proliferation-associated keratins

Journal of Investigative Dermatology

Volumn 119, Issue 2, 2002, Pages 403-410

  Hattori, Naoko ^a   Komine, Mayumi ^a   Yano, Shoichiro ^a   Kaneko, Takehiko ^a   Hanakawa, Yasushi ^b   Hashimoto, Koji ^b   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b EHIME UNIVERSITY   (Japan)

Author keywords

ex vivo; NF B; STAT1

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHLORAMPHENICOL ACETYLTRANSFERASE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; KERATIN; KERATIN K17; KERATIN K6; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ASSAY; EPIDERMIS; GENE TRANSFER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; WESTERN BLOTTING;

EID: 0036036378     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01843.x     Document Type: Article

References (29)

1. Human epidermal keratinocyte: Keratinization processes
2. Up-regulation of keratin 17 expression in human HaCaT keratinocytes by interferon-γ
3. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
4. Differential extraction of keratin subunits and filaments from normal human epidermis
5. Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations
6. Intermediate filaments. Structure, dynamics, function, and disease
7. Changes in keratin gene expression during terminal differentiation of the keratinocyte
8. Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes
9. Comparison of methods for transfection of human epidermal keratinocytes
10. Epidermal growth factor and transforming growth factor α specifically induce the activation- and hyperproliferation-associated keratins 6 and 16
11. Disease-activated transcription factor: Allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17
12. Regulation of epidermal expression of keratin K17 in inflammatory skin diseases
13. Inflammation versus proliferative processes in epidermis
14. Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes
15. Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro
16. Regulatory effects of antipsoriatic agents on interleukin-1 alpha production by human keratinocytes stimulated with gamma interferon in vitro
17. Characterization of nuclear protein binding sites in the promoter of keratin K17 gene
18. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
19. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
20. Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6
21. Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes
22. Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB
23. Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1α and IL-1 receptor antagonist
24. Convergence of TNFα and IFNγ signaling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/κB promoter element
25. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways
26. Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon γ
27. Transcriptional activation of psoriasis-associated cytokeratin K17 by interferon-gamma. Analysis of gamma-interferon activation sites
28. IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production
29. Monoclonal antibody analysis of keratin expression in epidermal diseases: A 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes