gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

Experimental Cell Research

Volumn 280, Issue 1, 2002, Pages 24-32

  Erices, Alejandro ^a,b   Conget, Paulette ^a   Rojas, Cecilia ^a   Minguell, José J ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b CLÍNICA LAS CONDES   (Chile)

Author keywords

gp130; Interleukin 6; Interleukin 6 receptor; Mesenchymal stem cells; Osteogenic differentiation

Indexed keywords

ALKALINE PHOSPHATASE; DEXAMETHASONE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; STAT3 PROTEIN;

ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURFACE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MESENCHYME CELL; OSTEOBLAST; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

EID: 0036031676     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5627     Document Type: Article

References (39)

1. Prockop, D. J. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276, 71-74.
2. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., and Marshak, D. R. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147.
3. Minguell, J. J., Erices, A., and Conget, P. (2001). Mesenchymal stem cells. Exp. Biol. Med. 226, 507-520.
4. Conget, P. A., Allers, C., and Minguell, J. J. (2001). Identification of a discrete population of human bone marrow-derived mesenchymal cells, exhibiting properties of uncommitted progenitors. J. Hemathoter. Stem Cell Res. 10, 749-758.
5. Pereira, R. F., Halford, K. W., O'Hara, M. D., Leeper, D. B., Sokolov, B. P., Pollard, M. D., Bagasra, O., and Prockop, D. J. (1995). Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc. Natl. Acad. Sci. USA 92, 4857-4861.
6. Kuznetsov, S. A., Friedenstein, A. J., and Robey, P. G. (1997). Factors required for bone marrow fibroblast colony formation in vitro. Br. J. Haematol. 97, 561-570.
7. Rickard, D. J., Kassem, M., Hefferan, T. E., Sarkar, G., Spelsberg, T. C., and Riggs, B. L. (1996). Isolation and characterization of osteoblast precursor cells from human bone marrow. J. Bone Miner. Res. 11, 312-324.
8. Gori, F., Thomas, T., Hicok, K. C., Spelsberg, T. C., and Riggs, B. L. (1999). Differentiation of human marrow stromal precursor cells: Bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J. Bone Miner. Res. 14, 1522-1535.
9. Grigoriadis, A. E., Heersche, J. N., and Aubin, J. E. (1988). Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: Effect of dexamethasone. J. Cell Biol. 106, 2139-2151.
10. Bruder, S. P., Jaiswal, N., and Haynesworth, S. E. (1997). Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive sub-cultivation and following cryopreservation. J. Cell. Biochem. 64, 278-294.
11. Cheng, Su-Li, Yang, J. W., Rifas, L., Zhang, Shu-Fang, and Avioli, L. (1994). Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone. Endocrinology 134, 277-286.
12. Beresford, J. N., Bennett J. H., Devlin C., Leboy P. S., and Owen M. E. (1992). Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 102, 341-351.
13. Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B., and Riggs, B. L. (1999). Leptin acts on human marrow stromal cells to enhance differentietion to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140, 1630-1638.
14. Bellido, T., Borba, V. Z. C., Roberson, P., and Manolagas, S. C. (1997). Activation of the janus kinase/stat (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation. Endocrinology 138, 3666-3676.
15. Manolagas, E. S. (1998). The role of IL-6 type cytokines and their receptors in bone. Ann. N. Y. Acad. Sci. 840, 194-204.
16. Metcalf, D., and Gearing, D. P. (1989). Fatal syndromes in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA 86, 5948-5952.
17. Onyia, J. E., Sato, M., Hulman, I., Cole, H., Tu, Y., Miles, R., Zeng, G., and Hock, J. M. (1997). In vivo effects of IL-6 on rat bone: Increased BMD and osteoprogenitor CFU-F formation efficiency. J. Bone Miner. Res. 12, S326.
18. Ogasawara, H., Tsuji, T., Hirano, D., Aoki, Y., Nakamura, M., and Kodama, H. (1996). Induction of IL-6 production by bone marrow stromal cells on the adhesion of IL-6-dependent hematopoietic cells. J. Cell Physiol. 169, 209-216.
19. Almeida, G. D., Porada, C. D., St. Jeor, S., and Ascensao, J. L. (1994). Human cytomegalovirus alters interleukin-6 production by endothelial cells. Blood 83, 370-376.
20. Majumdar, M. K., Thiede, M. A., Mosca, J. D., Moorman, M., and Gerson, S. L. (1998). Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J. Cell Physiol. 176, 57-66.
21. Peters, M., Müller, A. M., and Rose-John, S. (1998). Interleukin-6 and soluble interleukin-6 receptor. Direct stimulation of gp130 and hematopoiesis. Blood 92, 3495-3504.
22. Kishimoto, T., Akira, S., Narazaki, M., and Taga, T. (1995). Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254.
23. Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki, K., Taga, T., Kishimoto, T., and Suda, T. (1993). Soluble IL-6 receptor triggers osteoclast formation by interleukin-6. Proc. Natl. Acad. Sci. USA 90, 11924-11931.
24. Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N., and Fuller, G. M. (2001). The soluble interleukin 6 receptor: Mechanisms of production and implications in disease. FASEB J. 15, 43-58.
25. Conget, P. A., and Minguell, J. J. (1999). Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J. Cell Physiol. 181, 67-73.
26. Erices, A., Conget, P., and Minguell, J. J. (2000). Mesenchymal progenitor cells in human umbilical cord blood. Br. J. Haematol. 109, 235-242.
27. Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., and Hedrick, M. H. (2001). Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng. 7, 211-228.
28. Nishimura, A., Moriyama, K., Yasukawa, K., Mundy, G., and Yoneda, T. (1998). Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells. J. Bone Miner. Res. 13, 777-785.
29. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. G., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997). Targeted disruption of Cbfa-1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
30. Stanton, R. P., Hobson, G. M., Montgomery, B. E., Moses, P. A., Smith-Kirwin, S. M., and Funanage, V. L. (1999). Glucocorticoids decrease interleukin-6 levels and induce mineralization of cultured osteogenic cells from children with fibrous dysplasia. J. Bone Miner. Res. 14, 1104-1113.
31. Haynesworth, S. E., Baber, M. A., and Caplan, A. I. (1992). Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 13, 69-80.
32. Galmiche, M. C., Koteliansky, V. E., Briere, J., Herve, P., and Charbord, P. (1993). Stromal cells from human long-term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway. Blood 82, 66-76.
33. Taguchi, Y., Yamamoto, M., Llámate, T., Lin, S-C. Mocharla, H., DeTogni, P., Nakayama, N., Boyce, B., Abe, E., and Manolagas, S. C. (1998). Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc. Assoc. Am. Physicians 110, 559-574.
34. 3 on differentiation of a human osteosarcoma (MG-63). J. Biol. Chem. 267, 8943-8949.
35. Bellido, T., Stahl, N., Farruggella, T. J., Borba, V., Yancopoulos, G. D., and Manolagas, S. (1996). Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J. Clin. Invest. 97, 431-437.
36. Masera, R. G., Dovio, A., Sartori, M. L., Racca, S., and Angeli, A. (2000). Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. Z. Rheumatol. 59 (Suppl 2), II/103-107.
37. Paysant, J., Blanque, R., Vasse, M., Soria, J., and Gardner, C. R. (2000). Factors influencing the effect of the soluble IL-6 receptor on IL-6 responses in HepG2 hepatocytes. Cytokine 12, 774-779, doi:10.1006/cyto.1999.0649.
38. Klouche, M., Bhakdi, S., Hemmes, M., and Rose-John, S. (1999). Novel path to activation of vascular smooth muscle cells: Up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163, 4583-4589.
39. Watt, F. M., and Hogan, B. L. M. (2000). Out of eden: Stem cells and their niches. Science 287, 1427-1430.