Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population

Experimental and Clinical Endocrinology and Diabetes

Volumn 110, Issue 5, 2002, Pages 223-229

  Kaňková, Kateřina ^a   Jansen, E H J M ^a   Marova I ^a   Stejskalova A ^a   Pacal L ^a   Muzik J ^a   Vacha J ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Diabetic complications; Ferritin; Hereditary hemochromatosis; HFE; Iron; Type 2 diabetes mellitus

Indexed keywords

FERRITIN; HFE PROTEIN; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; INSULIN; MEMBRANE PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CZECH REPUBLIC; DISEASE SEVERITY; FEMALE; FERRITIN BLOOD LEVEL; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE INTOLERANCE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; POPULATION; PREVALENCE; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; BLOOD; BODY CONSTITUTION; CASE CONTROL STUDY; CAUCASIAN; CROSS-SECTIONAL STUDY; GENETIC POLYMORPHISM; GENETICS; GLUCOSE BLOOD LEVEL; HEMOCHROMATOSIS; HOMOZYGOTE; METABOLISM; MIDDLE AGED; SEXUAL DEVELOPMENT;

ADULT; AGED; AMINO ACID SUBSTITUTION; BLOOD GLUCOSE; BODY CONSTITUTION; CASE-CONTROL STUDIES; CAUCASOID RACE; CROSS-SECTIONAL STUDIES; CZECH REPUBLIC; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FEMALE; FERRITIN; GENOTYPE; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMAN; INSULIN; MALE; MEMBRANE PROTEINS; MIDDLE AGE; POLYMORPHISM (GENETICS); SEX CHARACTERISTICS; SUPPORT, NON-U.S. GOV'T; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FERRITINS; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0036024165     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-33071     Document Type: Article

References (38)

1. Role of oxidative stress in development of complications in diabetes
2. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
3. Genetic hemochromatosis, a Celtic disease: Is it now time for population screening?
4. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients
5. Prevalence of genetic hemochromatosis in a cohort of Italian patients with diabetes mellitus
6. Molecular genetics of hemochromatosis
7. Mutations in HFE, the hemochromatosis candidate gene, in patients with NIDDM
8. Clinical characteristics of type 2 diabetes in patients with mutations of HFE
9. Prevalence of hereditary aemochromatosis in late-onset type 1 diabetes mellitus: A retrospective study
10. Plasma ferritin and type 2 diabetes mellitus: A critical review
11. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
12. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
13. Serum ferritin as a component of the insulin resistance syndrome
14. C282Y and H63D mutations of the hemochromatosis candidate gene in type 2 diabetes
15. Diabetes and serum ferritin concentration among U.S. adults
16. C282Y mutation in HFE (haemochromatosis) gene and type 2 diabetes
17. What's new in hemochromatosis
18. Localization of iron transport and regulatory proteins in human cells
19. Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis
20. Factors affecting glucose tolerance in hereditary hemochromatosis
21. Polymorphism in intron 4 of HFE may cause overestimation of C282Y homozygote prevalence in haemochromatosis
22. Polymorphisms 1704G/Tand 2184A/G in the RAGE gene are associated with antioxidant status
23. Glucose enhancement of LDL oxidation is strictly metal ion dependent
24. Climacteric symptoms in a postmenopausal Czech population
25. Ferritin and the response to oxidative stress
26. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
27. Prevalence of genetic haemochromatosis among diabetic patients
28. Transition metals bind to glycated proteins forming redox active "glycochelates": Implications for the pathogenesis of certain diabetic complications
29. Glycochelates and the etiology of diabetic peripheral neuropathy
30. The haemochromatotic human pancreas: A quantitative immunohistochemical and ultrastructural study
31. Multicentric origin of hemochromatosis gene (HFE) mutations
32. Hemochromatosis in Ireland and HFE
33. Relation between iron stores and non-insulin dependent diabetes in men: Case-control study
34. Prevalence of HFE (hemochromatosis gene) mutations in unselected male patients with type 2 diabetes
35. Role of the Maillard reaction in diabetes mellitus and diseases of aging
36. Body iron stores are associated with serum insulin and blood glucose concentrations population study in 1,013 eastern Finnish men
37. The prevalence of hereditary haemochromatosis in a diabetic population
38. Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells