Ferritin and desferrioxamine attenuate xanthine oxidase-dependent leak in isolated perfused rat lungs

Inflammation

Volumn 26, Issue 4, 2002, Pages 153-159

  Hybertson, Brooks M ^a   Connelly, Kevin G ^a   Buser, Raquel T ^a   Repine, John E ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute lung injury; Antioxidants; Ferritin; Iron; Oxidants

Indexed keywords

DEFEROXAMINE; FERRITIN; IRON; IRON CHELATING AGENT; PURINE; PURINE DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHINE OXIDASE; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; IN VITRO STUDY; LUNG; METABOLISM; PERFUSION; PERMEABILITY; RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; LUNG INJURY; LUNG PERFUSION; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RESPIRATORY DISTRESS SYNDROME;

ANIMALS; DEFEROXAMINE; FERRITINS; IRON; IRON CHELATING AGENTS; LUNG; PERFUSION; PERMEABILITY; PURINES; RATS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; XANTHINE OXIDASE; ANIMAL; FERRITIN; IN VITRO; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0036022763     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016511611435     Document Type: Article

References (46)

1. Reactive oxygen species in acute lung injury
2. Scientific perspectives on adult respiratory distress syndrome
3. Pathogenesis of the adult respiratory distress syndrome: Evidence of oxidant activity in bronchoalveolar lavage fluid
4. Adult respiratory distress syndrome: A radical perspective
5. Vitamin E deficiency and lipoperoxidation during adult respiratory distress syndrome
6. Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome
7. Oxidant activity in expired breath of patients with adult respiratory distress syndrome
8. Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS
9. Oxidative damage to plasma proteins in adult respiratory distress syndrome
10. Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema
11. Differences in tocopherol-lipid ratios in ARDS and non-ARDS patients
12. Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome
13. Ferritin: A cytoprotective antioxidant strategem of endothelium
14. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases
15. Superoxide dependent iron release from ferritin in inflammatory diseases
16. Reactive oxygen species and iron - A dangerous partnership in inflammation
17. Most free-radical injury is iron-related: It is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin
18. Markers for predicting the development of acute respiratory distress syndrome
19. Serum ferritin as a predictor of the acute respiratory distress syndrome
20. Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome
21. Mediation of IgA induced lung injury in the rat. Role of macrophages and reactive oxygen products
22. Effect of reactive oxygen metabolites on endothelial permeability: Role of nitric oxide and iron
23. Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase
24. Supercritical fluid-aerosolized vitamin E pretreatment decreases leak in isolated oxidant-perfused rat lungs
25. Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion
26. Circulating xanthine oxidase: Potential mediator of ischemic injury
27. Permeability of isolated rat lungs perfused with purine and xanthine oxidase under constant perfusing pressure
28. Liver ischemia-reperfusion increases pulmonary permeability in rat: Role of circulating xanthine oxidase
29. Plasma xanthine oxidase activity in patients with ARDS
30. Ischemia-reperfusion in humans: Appearance of xanthine oxidase activity
31. Circulating xanthine oxidase in human ischemia reperfusion
32. Anthrone in estimating low concentrations of sucrose
33. Protection by deferoxamine from endothelial injury: A possible link with inhibition of intracellular xanthine oxidase
34. Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro
35. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
36. Plasma hypoxanthine levels in ARDS: Implications for oxidative stress, morbidity, and mortality
37. Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced acute lung injury
38. Vasoactive intestinal peptide prevents lung injury due to xanthine/xanthine oxidase
39. Hemoglobin potentiates oxidant injury in isolated rat lungs
40. Nutritional iron restriction diminishes acute complement-dependent lung injury
41. Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress
42. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
43. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages
44. Iron and the sex difference in heart disease risk
45. Primary plasma antioxidants in adult respiratory distress syndrome patients: Changes in iron-oxidizing, iron-binding, and free radical-scavenging proteins
46. Use of iron chelators in preventing hydroxyl radical damage: Adult respiratory distress syndrome as an experimental model for the pathophysiology and treatment of oxygen-radical-mediated tissue damage