Myofibroblast accumulation correlates with the formation of fibrotic tissue in a rat air pouch model

Journal of Rheumatology

Volumn 29, Issue 8, 2002, Pages 1698-1707

  Bjärdahlen, Anette ^a   Önnervik, Per Ola ^a   Westergren Thorsson, Gunilla ^a   Malmström, Anders ^a   Särnstrand, Bengt ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Air pouch; Arthritis; Cartilage; Myofibroblast; Pannus; Proteoglycan

Indexed keywords

COLLAGEN; HYALURONIC ACID; PROTEOGLYCAN; DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CELL INFILTRATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROSIS; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; NONHUMAN; PANNUS; PATHOGENESIS; PRIORITY JOURNAL; RAT; ANIMAL; ARTICULAR CARTILAGE; CELL COUNT; COTTON; DISEASE MODEL; FEMUR HEAD; FIBROBLAST; GRANULATION TISSUE; MALE; METABOLISM; METHODOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT; TRANSPLANTATION;

ANIMAL; CARTILAGE, ARTICULAR; CELL COUNT; COLLAGEN; DISEASE MODELS, ANIMAL; DNA; EXTRACELLULAR MATRIX; FEMUR HEAD; FIBROBLASTS; FIBROSIS; GOSSYPIUM; GRANULATION TISSUE; HYALURONIC ACID; MALE; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0036021965     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. The use of the air pouch to study experimental synovitis and cartilage breakdown
2. Collagen-induced arthritis in mice: An animal model to study the pathogenesis of rheumatoid arthritis
3. What we learn from arthritis models to benefit arthritis patients
4. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice
5. Tissue and intracellular pH in normal periarticular soft tissue and during different phases of antigen induced arthritis in the rat
6. A modified mouse air pouch model for evaluating the effects of compounds on granuloma induced cartilage degradation
7. The pharmacological modulation of angiogenesis in chronic granulomatous inflammation
8. The six-day-old rat air pouch model of inflammation: Characterization of the inflammatory response to carrageenan
9. Induction of a silica air-pouch granuloma in rat
10. Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes
11. Myofibroblast
12. The biology of the myofibroblast
13. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
14. Functions of cell surface heparan sulfate proteoglycans
15. Binding, internalization, and degradation of antiproliferative heparan sulfate by human embryonic lung fibroblasts
16. Retardation of articular cartilage degradation by glycosaminoglycan polysulfate, pentosan polysulfate, and DH-40J in the rat air pouch model
17. A simple, rapid, and sensitive DNA assay procedure
18. Determinations of hydroxyproline
19. A convenient radiometric assay for hyaluronan
20. Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue
21. Size-dependent separation of proteoglycans by electrophoresis in gels of pure agarose
22. Isolation and characterisation of dermatan sulphate proteoglycans from bovine sclera
23. Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: A pivotal role for stromelysin-I in cartilage destruction
24. Gelatinase is the main matrix metalloproteinase involved in granuloma-induced cartilage degradation
25. Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma
26. Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA
27. Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44
28. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
29. Cell detachment mediated by hyaluronic acid
30. Increased hyaluronate synthesis is required for fibroblast detachment and mitosis
31. Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for T cell involvement and the immunosuppressive influence of keratan sulfate on recognition of T and B cell epitopes
32. Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage
33. Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation
34. Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats
35. Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: Effects of osteopontin on the release of collagenase I from articular chondrocytes and synovial fibroblasts
36. Connective tissue markers of rheumatoid arthritis
37. Cellular functions of proteoglycans - An overview
38. Growth factors in the extracellular matrix
39. Mesenchymal precursor cells in the blood of normal individuals
40. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
41. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway