The negative regulation of platelet function: Extending the role of the ITIM

Trends in Cardiovascular Medicine

Volumn 12, Issue 5, 2002, Pages 213-219

  Gibbins, Jonathan M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; RECEPTOR SUBTYPE; TYROSINE; IMMUNOGLOBULIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL MODEL; BLOOD VESSEL INJURY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE;

ANTIGENS, CD31; BLOOD PLATELETS; HUMAN; PLATELET ACTIVATION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; THROMBOSIS; HUMANS;

EID: 0036021112     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(02)00164-0     Document Type: Review

References (45)

1. Molecular and cellular properties of PECAM-1 (endoCAM/CD31); A novel vascular cell-cell adhesion molecule
2. Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by Fc gamma RIIB
3. 3 as a heterotypic ligand for CD31/PECAM-1
4. A novel phosphotyrosine motif with a critical amino acid at position-2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1
5. Ligation of CD31(PECAM-1) on endothelial cells increases adhesive function of αvβ3 integrin and enhances β1 integrin mediated adhesion of eosinophils to endothelial cells
6. Negative regulation of collagen receptor signalling by PECAM-1 in human platelets
7. PECAM-1 signalling inhibits the activation of human platelets
8. PECAM-1; a negative regulator of platelet activation?
9. Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases
10. αR and the natural killer receptors
11. Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1); CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions
12. Thrombin induced association of SHP-2 with multiple tyrosine phosphorylated proteins in human platelets
13. Ligation of CD31/PECAM-1 modulates the function of lymphocytes, monocytes and neutrophils
14. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets
15. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain
16. Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release
17. Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signaling
18. Recruitment and activation of SHP-1 protein tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1)
19. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2
20. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation
21. Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions
22. A family of proteins that inhibit signaling through tyrosine kinase receptors
23. PECAM-1 (CD31) expression modulates bleeding time in vivo
24. Endothelial cell tube formation depends on cadherin and CD31 interactions with filamentous actin
25. Tyrosine phosphorylation of P-selectin in intact platelets and in a disulfide-linked complex with immunoprecipitated pp60(C-Src)
26. PECAM-1 is required for transendothelial migration of leukocytes
27. Inhibition of antigen-receptor signaling by platelet endothelial cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck)
28. Switched at birth; a new family for PECAM-1
29. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
30. Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen
31. Murine platelet endothelial cell adhesion molecule (PECAM-1/CD31) modulates β2 integrins on lymphokine-activated killer cells
32. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
33. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-γ1 with PECAM-1/CD31
34. Immune inhibitory receptors
35. The small GTPase, Rap1, mediates CD31-induced integrin adhesion
36. Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles
37. CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion
38. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo
39. Platelet/endothelial cell adhesion molecule-1 serves as a co-stimulatory agonist receptor that modulates integrin dependent adhesion and aggregation of human platelets
40. Lack of in vivo function of CD31 in vascular thrombosis
41. The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen
42. Collagen receptor signalling in platelets; extending the role of the ITAM
43. Binding properties and inhibition of platelet aggregation by a monoclonal antibody to CD31 (PECAM-1)
44. Localization of multiple functional domains on human pECAM-1 (CD31) by monoclonal-antibody epitope mapping
45. Integrin activation by regulated dimerization and oligomerization of PECAM-1 from within the cell