Smoking, lung cancers and their TP53 mutations

Mutagenesis

Volumn 17, Issue 4, 2002, Pages 279-280

  Cooper, Colin S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCYCLIC AROMATIC HYDROCARBON; PROTEIN P53;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DNA STRAND; GENE MUTATION; GENOTOXICITY; HUMAN; LUNG CANCER; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; SMOKING; SUPPRESSOR GENE; ADENOCARCINOMA; GENETICS; LUNG TUMOR; REVIEW; SQUAMOUS CELL CARCINOMA;

NICOTIANA TABACUM;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; DNA METHYLATION; HUMANS; LUNG NEOPLASMS; POINT MUTATION; SMOKING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036020626     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/17.4.279     Document Type: Article

References (16)

1. Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the aetiology of cancer
2. Carcinogens preferentially bind at methylated CpG in the TP53 mutational hot spots
3. Mutation spectrum of cigarette smoke condensate in Salmonella: Comparison to mutations in smoking-associated tumors
4. Cytosine methylation determines hot spots of DNA damage in the human TP53 gene
5. Patterns of TP53 G→T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
6. TP53 tumor suppressor gene: From the basic research laboratory to the clinic-an abridged historical perspective
7. Ubiquitous and tenacious methylation of the CpG site in codon 248 of the TP53 gene may explain its frequent appearance as a mutational hot spot in human cancer
8. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and TP53 genes
9. Human lung cancer and TP53: The interplay between mutagenesis and selection
10. Characterisation of the mutational profile of (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphorisbosyltransferase gene in repair-deficient Chinse hamster V-H1 cells
11. How stereochemistry affects mutagenesis by N2-deoxyguanosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene: Configuation of the adduct bond is more important than those of the hydroxyl groups
12. The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G→A) in a 5′-CGT-3′ sequence context
13. The major, N2-dG adduct of (+)-anti-B[a]PDE induces G→A mutations in a 5′-AGA-3′ sequence context
14. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons
15. Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo(a)pyrene
16. The relationship between benzo(a)pyrene-induced mutagenesis and carcinogenesis in repair-deficient cockayne syndrome group B mice