Lower concentrations of clarithromycin suppress urease activity, motility, and binding to gastric epithelial cells in Helicobacter pylori isolates

Digestive and Liver Disease

Volumn 34, Issue 7, 2002, Pages 489-497

  Obata, K ^a   Ina, K ^a   Ohta, M ^a   Kawamura Sato, K ^a   Tsuzuki, T ^a   Ando, T ^a   Kusugami, K ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Clarithromycin; Helicobacter pylori; Virulence factor

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; OMEPRAZOLE; TINIDAZOLE; UREASE; VIRULENCE FACTOR; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; ATTENUATION; BACTERIAL COUNT; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME REPRESSION; EPITHELIUM CELL; ERADICATION THERAPY; GASTRITIS; HELICOBACTER PYLORI; HUMAN; INCUBATION TIME; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIC ULCER; STOMACH EPITHELIUM; TREATMENT FAILURE; BINDING COMPETITION; COMPARATIVE STUDY; CYTOLOGY; DISEASE PREDISPOSITION; ENZYMOLOGY; GASTROINTESTINAL MOTILITY; GENETICS; HELICOBACTER INFECTION; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; STOMACH; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; BINDING, COMPETITIVE; CLARITHROMYCIN; DISEASE SUSCEPTIBILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MICROBIAL; EPITHELIAL CELLS; GASTROINTESTINAL MOTILITY; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; PEPTIC ULCER; STOMACH; TREATMENT OUTCOME; UREASE;

EID: 0036020533     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1590-8658(02)80107-4     Document Type: Article

References (37)

1. Hypothesis on the pathogenesis and natural history of Helicobacter pylori-induced inflammation
2. Effect of treatment of infection on the long-term recurrence of gastric or duodenal ulcer: A randomized, controlled study
3. Prevention of ulcer recurrence after eradication of Helicobacter pylori: A prospective long-term follow-up study
4. Helicobacter pylori eradication in the healing and recurrence of benign gastric ulcer: A two-year, double-blind, placebo controlled study
5. Highly significant change of the clinical course of relapsing and complicated peptic ulcer disease after cure of Helicobacter pylori infection
6. Current European concepts in the management of Helicobacter pylori infection
7. Randomised study of the efficacy of omeprazole and clarithromycin with either amoxycillin or metronidazole in the eradication of Helicobacter pylori in screened primary care patients
8. Epidemiology and mechanism of antibiotic resistance in Helicobacter pylori
9. Relationship between eradication therapy and clarithromycin-resistant Helicobacter pylori in Japan
10. Therapy and drug resistance in Helicobacter pylori infection
11. The MACH2 study: Role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies
12. Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations
13. Suppression of virulence factors of Pseudomonas aeruginosa by erythromycin
14. Effect of subinhibitory concentration of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis
15. Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibiotics
16. Macrolides for the treatment of Pseudomonas aeruginosa infections?
17. Biofilm disease: Its clinical manifestation and therapeutic possibilities of macrolides
18. Differential normalization of mucosal interleukin-8 and interleukin-6 activity after Helicobacter pylori eradication
19. Clarithromycin increases the release of heat shock protein B from Helicobacter pylori
20. Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin - Influence on treatment outcome
21. Comparison between in vivo and in vitro chemokine production in Helicobacter pylori infection
22. A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori
23. Simultaneous colonization of Helicobacter pylori with and without mutations in the 23S rRNA gene in patients with no history of clarithromycin exposure
24. Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: Unique action selective for H. pylori cells
25. Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: Both flagellin subunits, Fla A and Fla B, are necessary for full motility in Helicobacter species
26. Flagellar preparations from Pseudomonas aeruginosa: Isolation and characterization
27. Optimized BlaM-transposon shuttle mutagenesis of Helicobacter pylori allows the identification of novel genetic loci involved in bacterial virulence
28. Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells
29. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori
30. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori
31. Pathogenic properties of Helicobacter pylori
32. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets
33. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production
34. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage
35. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment
36. A flagellar-specific ATPase (FilI) is necessary for flagellar export in Helicobacter pylori
37. Campylobacter pyloridis and gastritis: Association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium