Human macrophage-mediated biodegradation of polyurethanes: Assessment of candidate enzyme activities

Biomaterials

Volumn 23, Issue 19, 2002, Pages 3969-3975

  Labow, Rosalind S ^a   Meek, Erin ^a   Matheson, Loren A ^a   Santerre, J Paul ^b  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biodegradation; Carboxylesterase; Cholesterol esterase; Monocyte derived macrophages; Polyurethanes

Indexed keywords

BIODEGRADATION; BIOMATERIALS; BIOSYNTHESIS; ENZYME INHIBITION; IMMUNOLOGY; POLYMERS;

MONOCYTE DERIVED MACROPHAGE (MDM);

POLYURETHANES;

4 NITROPHENYLBUTYRATE; ALCOHOL DERIVATIVE; BENZYLSULFONYL FLUORIDE; BIOMATERIAL; BUTANEDIOL; BUTYRIC ACID DERIVATIVE; CARBON 14; CARBOXYLESTERASE; CHOLESTEROL ESTERASE; CYANIC ACID DERIVATIVE; ENZYME ACTIVATOR; ESTERASE INHIBITOR; FLUORIDE SODIUM; HEXANE DIISOCYANATE; PARAOXON; POLYCARBONATE; POLYURETHAN; SERINE PROTEINASE INHIBITOR; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; 4 TOLUENESULFONYL FLUORIDE; 4-TOLUENESULFONYL FLUORIDE; DNA; PROTEINASE INHIBITOR; TOLUENESULFONIC ACID DERIVATIVE;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; INCUBATION TIME; ISOTOPE LABELING; MACROPHAGE; NORMAL HUMAN; PRIORITY JOURNAL; SYNTHESIS; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; IMMUNOBLOTTING; METABOLISM; MONOCYTE; TIME;

BIOCOMPATIBLE MATERIALS; CARBOXYLIC ESTER HYDROLASES; CELLS, CULTURED; CHOLESTEROL ESTERASE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; IMMUNOBLOTTING; MACROPHAGES; MONOCYTES; POLYURETHANES; PROTEASE INHIBITORS; SODIUM FLUORIDE; SUPPORT, NON-U.S. GOV'T; TAUROCHOLIC ACID; TIME FACTORS; TOSYL COMPOUNDS; CARBOXYLESTERASE; HUMANS;

EID: 0036020044     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(02)00137-0     Document Type: Article

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