Tumor cell-targeting by phage-displayed peptides

Cancer Gene Therapy

Volumn 9, Issue 7, 2002, Pages 606-612

  Rasmussen, Ulla B ^a   Schreiber, Valerie ^a   Schultz, Huguette ^a   Mischler, Fabienne ^a   Schughart, Klaus ^a  

^a TRANSGENE S A   (France)

Author keywords

Human cancer cells; Peptide display; Phage display; Subtraction; Targeting; WiDr cells

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER; PEPTIDE; IMMUNOGLOBULIN G; PEPTIDE LIBRARY;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CELL ADHESION; COLORECTAL CANCER; CONTROLLED STUDY; DRUG SPECIFICITY; GENE TRANSFER; HUMAN; HUMAN CELL; PHAGE DISPLAY; PRIORITY JOURNAL; TARGET CELL DESTRUCTION; TUMOR CELL; CELL CULTURE; GENE THERAPY; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; PROTEIN BINDING;

GENE THERAPY; HUMAN; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; TRANSFECTION; TUMOR CELLS, CULTURED; HUMANS;

EID: 0036019377     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700476     Document Type: Article

References (18)

1. Genes expressed in human tumor endothelium
2. Vascular targeting with phage peptide libraries
3. Alpha v integrins as receptors for tumor targeting by circulating ligands
4. Biodistribution of filamentous phage-Fab in nude mice
5. Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display
6. Selection of tumor-specific internalizing human antibodies from phage libraries
7. Identification of a human anti-CD55 single-chain Fv by subtractive panning of a phage library using tumor and nontumor cell lines
8. Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries
9. In vivo selection of sFv from phage display libraries
10. Elucidation of muscle-binding peptides by phage display screening
11. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
12. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display
13. Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments
14. An RGD-oligolysine peptide: A prototype construct for integrin-mediated gene delivery
15. DNA binds and activates complement via residues 14-26 of the human C1q A chain
16. HER2/neu tyrosine kinases in vitro and in vivo
17. Viral vector targeting
18. Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells