Lovastatin induces cell death in cardiomyocytes that is not reversible by coenzyme Q 10

Pharmacology and Toxicology

Volumn 90, Issue 6, 2002, Pages 343-345

  Rabkin, Simon W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MEVINOLIN; UBIDECARENONE; DRUG DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; UBIQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG SAFETY; EMBRYO; ENZYME KINETICS; ENZYME REGULATION; HEART MUSCLE CELL; HUMAN; HYPERCHOLESTEROLEMIA; MITOCHONDRIAL RESPIRATION; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; RHABDOMYOLYSIS; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHICK EMBRYO; CYTOLOGY; DRUG EFFECT; HEART MUSCLE;

ANIMAL; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MYOCARDIUM; SUPPORT, NON-U.S. GOV'T; UBIQUINONE; ANIMALS;

ANIMALIA;

EID: 0036018542     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.900609.x     Document Type: Article

References (16)

1. Effect of a long-term treatment with lovastatin or fenofibrate on hepatic and cardiac ubiquinone levels in cardiomyopathic hamster
2. Comparison of superoxide dismutase, allopurinol, coenzyme Q10, and glutathione for the prevention of warm ischemic injury
3. Influences of lovastatin administration on the respiratory burst of leukocytes and the phosphorylation potential of mitochondria in guinea pigs
4. Ubiquinone protects cultured neurons against spontaneous and excitotoxin-induced degeneration
5. Lovastatin decreases coenzyme Q levels in humans
6. Regulation of the mevalonate pathway
7. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
8. Coenzyme Q10 can in some circumstances block apoptosis, and this effect is mediated through mitochondria
9. COQ10 fails to protect brain against focal and global ischemia in rats
10. Effects of lovastatin and pravastatin on the survival of hamsters with inherited cardiomyopathy
11. Myopathy induced by HMG-CoA reductase inhibitors in rabbits: A pathological, electrophysiological, and biochemical study
12. Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes
13. 2+ channel activity and uncouples excitation from contraction in cardiac cells in culture
14. Lovastatin decreases coenzyme Q levels in rats
15. Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin
16. Dual involvement of coenzyme Q10 in redox signaling and inhibition of death signaling in rat heart mitochondria