SERCA2a and mitochondrial cytochrome oxidase expression are increased in hearts of exercise-trained old rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Tate, Charlotte A ^a   Helgason, Thorunn ^b   Hyek, Michael F ^b   Mcbride, R Perley ^b   Chen, Minhui ^b   Richardson, Michelle A ^b   Taffet, George E ^b  

^a UNIVERSITY OF HOUSTON   (United States)

^b NONE

Author keywords

actin; Fischer 344 rats; mitochondrial cytochrome oxidase; sarcoplasmic reticulum calcium adenosinetriphosphatase; SERCA2a gene

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL ENZYME;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; EXERCISE; GENE EXPRESSION; HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ANALYSIS;

EID: 33750838801     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.1.h68     Document Type: Article

References (22)

1. Balsam, A., and L. E. Leppo. Stimulation of the peripheral metabolism of L-thyroxine and 3,5,3′-L-triiodothyronine in the physically trained rat. Endocrinology 95: 299-302, 1974.
2. Biggs, R. B., R. M. Hanley, P. R. Morrison, and F. W. Booth. Cytochrome c mRNA levels decrease in senescent rat heart. Mech. Ageing Dev. 60: 285-293, 1991.
3. Bergmeyer, H. Cytochrome oxidase. In: Methods in Enzymatic Analysis, edited by H. Bergmeyer. Berlin: Verlag Chemie, 1983, p. 266-273.
4. Buttrick, P., A. Malhotra, S. Factor, D. Geenen, L. Leinwand, and J. Scheuer. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circ. Res. 68: 645-652, 1991.
5. Carrier, L., K. R. Boheler, C. Chassagne, D. de la Bastie, C. Wisnewsky, E. G. Lakatta, and K. Schwartz. Expression of the sarcomeric actin isogenes in the rat heart with development and senescence. Circ. Res. 70: 999-1005, 1992.
6. Chesky, J. A., S. LaFollette, M. Travis, and C. Fortado. Effect of physical training on myocardial enzyme activities in aging rats. J. Appl. Physiol. 55: 1349-1353, 1983.
7. Farrar, R. P., J. W. Stares, G. D. Cartee, P. Y. Oh, and H. L. Sweeney. Effects of exercise on cardiac myosin isozyme composition during the aging process. J. Appl. Physiol. 64: 880-883, 1988.
8. Gwathmey, J. K., M. T. Slawsky, C. L. Perreault, G. M. Briggs, J. P. Morgan, and J. Y. Wei. Effect of exercise conditioning on excitation-contraction coupling in aged rats. J. Appl. Physiol. 69: 1366-1371, 1990.
9. Hansford, R. G. Bioenergetics in aging. Biochim. Biophys. Acta 726: 41-80, 1983.
10. Kainulainen, H., and J. Komulainen. Effects of training on regional substrate oxidation in the hearts of ageing rats. Gerontology 35: 289-296, 1989.
11. Lakatta, E. G. Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73: 413-467, 1993.
12. 2+-ATPaSe and calsequestrin genes in rat heart daring ontogenic development and aging. Circ. Res. 69: 1380-1388, 1991.
13. 2+-ATPase of the rat heart. Circ. Res. 67: 230-234, 1990.
14. Narayanan, N. Differential alterations in ATP-supported calcium transport activities of sarcoplasmic reticulum, and sarcolemma of aging myocardium. Biochim. Biophys. Acta 678: 442-459, 1981.
15. Pagani, E. D., and R. J. Solaro. Coordination of cardiac myofibrillar and sarcotubular activities in rats exercised by swimming. Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H909-H915, 1984.
16. Starnes, J. W., R. E. Beyer, and D. W. Edington. Myocardial adaptations to endurance exercise in aged rats. Am. J. Physiol. 245 (Heart Circ. Physiol. 14): H560-H566, 1983.
17. Starnes, J. W., and W. L. Rumsey. Cardiac energetics and performance of exercised and food-restricted rats during aging. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H599-H608, 1988.
18. Swoap, S. J., F. Haddad, P. Bodell, and K. M. Baldwin. Effect of chronic energy deprivation on cardiac thyroid hormone receptor and myosin isoform expression. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E254-E260, 1994.
19. Taffet, G. E., and C. A. Tate. The MgATPase activity of rat cardiac sarcoplasmic reticulum is a function of the calcium ATPase protein. Arch. Biochem. Biophys. 299: 287-294, 1992.
20. Taffet, G. E., and C. A. Tate. CaATPase content is lower in cardiac sarcoplasmic reticulum isolated from old rats. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1609-H1614, 1993.
21. Tate, C. A., G. E. Taffet, E. K. Hudson, S. L. Blaylock, R. P. McBride, and L. H. Michael. Enhanced calcium uptake of cardiac sarcoplasmic reticulum in exercise-trained old rats. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H431-H435, 1990.
22. Tate, C. A., M. F. Hyek, and G. E. Taffet. Mechanisms for the responses of cardiac muscle to physical activity in old age. Med. Sci. Sports Exercise 26: 561-567, 1994.