Effect of hindlimb suspension and clenbuterol treatment on polyamine levels in skeletal muscle

Pharmacology

Volumn 65, Issue 3, 2002, Pages 145-154

  Abukhalaf, Imad K ^a   Von Deutsch, Daniel A ^a   Wineski, Lawrence E ^a   Silvestrov, Natalia A ^a   Abera, Saare A ^a   Sahlu, Sinafikish W ^a   Potter, David E ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Atrophy; Clenbuterol; Hindlimb suspension; Microgravity; Polyamines; Putrescine; Skeletal muscle; Spermidine; Spermine

Indexed keywords

CLENBUTEROL; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; EXTENSOR DIGITORUM LONGUS MUSCLE; GASTROCNEMIUS MUSCLE; IMMOBILIZATION; MALE; MICROGRAVITY; MUSCLE ATROPHY; MUSCLE HYPERTROPHY; MUSCLE MASS; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TISSUE LEVEL; ANIMAL; CHEMISTRY; DRUG EFFECT; FAST MUSCLE FIBER; ISOLATION AND PURIFICATION; METABOLISM; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER; SLOW MUSCLE FIBER; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-AGONISTS; ANIMAL; BIOGENIC POLYAMINES; CLENBUTEROL; HINDLIMB SUSPENSION; MALE; MUSCLE FIBERS, FAST-TWITCH; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE, SKELETAL; PUTRESCINE; RATS; RATS, SPRAGUE-DAWLEY; SPERMIDINE; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

EID: 0036016957     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000058041     Document Type: Article

References (63)

1. Hypogravity-induced atrophy of rat soleus and extensor digitorum longus muscles
2. Is skeletal muscle ready for long-term spaceflight and return to gravity?
3. Influence of spaceflight on rat skeletal muscle
4. Effect of spaceflight on the functional, biochemical, and metabolic properties of skeletal muscle
5. Skeletal muscle responses to unloading with special reference to man
6. Effect of short-duration spaceflight on thigh and leg muscle volume
7. Postsynaptic alpha 1- and alpha 2-adrenoceptors mediating the action of the sympathetic system on muscle spindles, in the rabbit
8. Alpha-adrenergic receptors in rat skeletal muscle
9. Distribution and quantification of beta 1-, beta 2-, and beta 3-adrenergic receptor subtype transcripts in porcine tissues
10. Growth hormone and the insulin-like growth factor system in myogenesis
11. IGF-I, growth hormone, and/or exercise effects on non-weight-bearing soleus of hypophysectomized rats
12. Anabolic influences of insulin-like growth factor I and/or growth hormone on the diaphragm of young rats
13. Stimulation of muscle growth by clenbuterol: Lack of effect on muscle protein biosynthesis
14. β-Agonist-induced alterations in organ weights and protein content: Comparison of racemic clenbuterol and its enantiomers
15. Effects of clenbuterol on contractile and biochemical properties of skeletal muscle
16. The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hind limb muscles from young male rats
17. Inhibition and reversal of denervation-induced atrophy by the β-agonist growth promoter clenbuterol
18. The effect of clenbuterol administration in utero and throughout lactation on pre- and postnatal muscle development in the rat
19. Clenbuterol, a β-adrenoreceptor agonist, increases relative muscle strength in orthopedic patients
20. Clenbuterol, a β-agonist, retards atrophy in denervated muscles
21. Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta 2-receptor agonist
22. Muscle-specific effects of hindlimb suspension and clenbuterol in mature male rats
23. Clenbuterol-induced regional and muscle-specific effects in suspended rats
24. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats
25. Effects of unweighting and clenbuterol on myosin light and heavy chains in fast and slow muscles of rat
26. Sensitivity of lipolysis and lipogenesis to dibutyryl-cAMP and beta-adrenergic agonists in swine adipocytes in vitro
27. Basolateral amygdala noradrenergic influences on memory storage age mediated by an interaction between beta- and alpha 1-adrenoceptors
28. Polyamines: New cues in cellular signal transduction
29. Influence of physical exercise on polyamine synthesis in the rat skeletal muscle
30. Plasma and muscle polyamine levels in aerobically exercised rats treated with salbutamol
31. Effect of the beta-adrenoceptor agonist clenbuterol and phytohaemagglutinin on growth, protein synthesis and polyamine metabolism of tissues of the rat
32. Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart
33. i and membrane transport in rat heart myocytes
34. Role of ornithine decarboxylase in cardiac growth and hypertrophy
35. Effect of clenbuterol on growth and body composition during food restriction in rats
36. The pharmacokinetics, metabolism, and tissue residues of beta-adrenergic agonists in livestock
37. Spaceflight and bone turnover: Correlation with a new rat model of weightlessness
38. Recovery of the rat skeleton from the adverse effects of simulated weightlessness
39. Hindlimb unloading of growing rats: A model for predicting skeletal changes during space flight
40. Antipyrine pharmacokinetics in the tail-suspended rat model
41. Examining potential drug therapies for muscular dystrophy utilizing the dy/dy mouse. I. Clenbuterol
42. Beta 2-adrenoceptor agonist-induced down-regulation after short-term exposure
43. Rat hindlimb unloading: Soleus histochemistry, ultrastructure, and electromyography
44. Skeletal muscle fiber, nerve, and blood vessel breakdown in space-flown rats
45. Inflight and postflight changes in skeletal muscles of SLS-1 and SLS-2 spaceflown rats
46. Distribution of myosin heavy chain isoforms in non-weight-bearing rat soleus muscle fibers
47. Five myofibrillar lesion types in eccentrically challenged, unloaded rat adductor longus muscle - A test model
48. Comparative analytical quantitation of clenbuterol in biological matrices using GC-MS and EIA
49. Measurement of protein using bicinchoninic acid
50. Supplementation of vitamin E may attenuate skeletal muscle immobilization atrophy
51. Hydroxyl radical generation in skeletal muscle atrophied by immobilization
52. Muscle necrosis by N-methylated p-phenylene-diamines in rats: Structure-activity relationships and correlation with free-radical production in vitro
53. Spermine partially normalizes in vivo antioxidant defense potential in certain brain regions in transiently hypoperfused rat brain
54. Antioxidant properties of di- and polyamines
55. Free radical-induced elevation of ornithine decarboxylase activity in developing rat brain slices
56. Spermine: An anti-oxidant and anti-inflammatory agent
57. Polyamines as modulators of lipoperoxidation
58. The physiological role of the polyamines
59. Biochemical characteristics of beta-adrenoceptors in rats after an 18-day spaceflight (LMS-STS78)
60. Central and peripheral noradrenergic responses to 14 days of spaceflight (SLS-2) or hindlimb suspension in rats
61. Increased beta-adrenergic responsiveness induced by 14 days exposure to simulated microgravity
62. Evidence for increased beta-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans
63. Muscle and serum changes with salbutamol administration in aerobically exercised rats