Role of nitric oxide in the development and partial reversal of allergen-induced airway hyperreactivity in conscious, unrestrained guinea-pigs

British Journal of Pharmacology

Volumn 123, Issue 7, 1998, Pages 1450-1456

  Schuiling, Martin ^a   Zuidhof, Annet B ^a   Bonouvrie, Monique A A ^a   Venema, Nicolette ^a   Zaagsma, Johan ^a   Meurs, Herman ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Airway hyperreactivity; Allergic asthma; Histamine; N nitro L arginine methyl ester; Nitric oxide

Indexed keywords

ALLERGEN; HISTAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OVALBUMIN;

AIRWAY OBSTRUCTION; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; FEMALE; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; ENZYME INHIBITORS; FEMALE; GUINEA PIGS; HISTAMINE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE;

EID: 0031889192     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701738     Document Type: Article

References (39)

1. AHLNER, J., ANDERSSON, R.G., TORFGARD, K. & AXELSSON, K.L. (1991). Organic nitrate esters: clinical use and mechanisms of actions. Pharmacol. Rev., 43, 351-423.
2. BARNES, P.J. (1990). Reactive oxygen species and airway inflammation. Free Radic. Biol. Med., 9, 235-243.
3. BARNES, P.J. & BELVISI, M.G. (1993). Nitric oxide and lung disease, Thorax. 48, 1034-1043.
4. BARNES, P.J. & LIEW, F.Y. (1995). Nitric oxide and asthmatic inflammation, Immunol. Today, 16, 128-130.
5. BORISH, L. & JOSEPH, B.Z. (1992). Inflammation and the allergic response. Med. Clin. North Am., 76, 765-787.
6. BROWN, R.H., ZERHOUNI, E.A. & HIRSHMAN, C.A. (1994). Reversal of bronchoconstriction by inhaled nitric oxide. Histamine versus methacholine. Am. J. Respir. Crit. Care Med., 150, 233-237.
7. DE BOER, J., MEURS, H., COERS, W., KOOPAL, M., BOTTONE, A.E., VISSER, A.C., TIMENS, W. & ZAAGSMA, J. (1996). Deficiency of nitric oxide in allergen-induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study. Br. J. Pharmacol., 119, 1109-1116.
8. DUPUY, P.M., SHORE, S.A., DRAZEN, J.M., FROSTELL, C., HILL, W.A. & ZAPOL, W.M. (1992). Bronchodilator action of inhaled nitric oxide in guinea pigs. J. Clin. Invest., 90, 421-428.
9. FISCHER, A., MUNDEL, P., PREISSLER, U., PHILIPPIN, B. & KUMMER, W. (1993). Nitric oxide synthase in guinea pig lower airway innervation. Neurosci. Lett., 149, 157-160.
10. FLAVAHAN, N.A., SLIFMAN, N.R., GLEICH, G.J. & VANHOUTTE, P.M. (1988). Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Role of the epithelium. Am. Rev. Respir. Dis., 138, 685-688.
11. FORSTERMANN, U., SCHMIDT, H.H., POLLOCK, J.S., SHENG, H., MITCHELL, J.A., WARNER, T.D., NAKANE, M. & MURAD, F. (1991). Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem. Pharmacol., 42, 1849-1857.
12. GLEIGH, G.J., FLAVAHAN, N.A., FUJISAWA, T. & VANHOUTTE, P.M. (1988). The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J. Allergy Clin. Immunol., 81, 776-781.
13. GUSTAFSSON, L.E., LEONE, A.M., PERSSON, M.G., WIKLUND, N.P. & MONCADA, S. (1991). Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem. Biophys. Res. Commun., 181, 852-857.
14. HAMID, Q., SPRINGALL, D.R., RIVEROS-MORENO, V., CHANEZ, P., HOWARTH, P., REDINGTON, A., BOUSQUET, J., GODARD, P., HOLGATE, S. & POLAK, J.M. (1993). Induction of nitric oxide synthase in asthma. Lancet, 342, 1510-1513.
15. HUIE, R.E. & PADMAJA, S. (1993). The reaction of NO with Superoxide. Free Radic. Res. Commun., 18, 195-199.
16. IGNARRO, L.J., BYRNS, R.E., BUGA, G.M., WOOD, K.S. & CHAUDHURI, G. (1988). Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and Superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J. Pharmacol. Exp. Ther., 244, 181-189.
17. KARLSSON, J.A., LANNER, A.S. & PERSSON, C.G. (1990). Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs. J. Pharmacol. Exp. Ther., 252, 863-868.
18. KHARITONOV, S.A., O'CONNOR, B.J., EVANS, D.J. & BARNES, P.J. (1995). Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am. J. Respir. Crit. Care Med., 151, 1894-1899.
19. KHARITONOV, S.A., YATES, D., ROBBINS, R.A., LOGAN SINCLAIR, R., SHINEBOURNE, E.A. & BARNES, P.J. (1994). Increased nitric oxide in exhaled in air of asthmatic patients. Lancet, 343, 133-135.
20. KOBZIK, L., BREDT, D.S., LOWENSTEIN, C.J., DRAZEN, J., GASTON, B., SUGARBAKER, D. & STAMLER, J.S. (1993). Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am. J. Respir. Cell Mol. Biol., 9, 371-377.
21. MASAKI, Y., MUNAKATA, M., AMISHIMA, M., HOMMA, Y. & KAWAKAMI, Y. (1994). In vivo, in vitro correlation of acetylcholine airway responsiveness in sensitized guinea pigs. The role of modified epithelial functions. Am. J. Respir. Crit. Care Med., 149, 1494-1498.
22. MONCADA, S. & HIGGS, A. (1993). The L-arginine-nitric oxide pathway. N. Engl. J. Med., 329, 2002-2012.
23. NIJKAMP, F.P., VAN DER LINDE, H.J. & FOLKERTS, G. (1993). Nitric oxide synthesis inhibitors induce airway hyperresponsiveness in the guinea pig in vivo and in vitro. Role of the epithelium. Am. Rev. Respir. Dis., 148, 727-734.
24. PERSSON, M.G., FRIBERG, S.G., HEDQVIST, P. & GUSTAFSSON, L.E. (1993). Endogenous nitric oxide counteracts antigen-induced bronchoconstriction. Eur. J. Pharmacol., 249, R7-8.
25. PERSSON, M.G. & GUSTAFSSON, L.E. (1993). Allergen-induced airway obstruction in guinea-pigs is associated with changes in nitric oxide levels in exhaled air. Acta Physiol. Scand., 149, 461-466.
26. PERSSON, M.G., MIDTVEDT, T., LEONE, A.M. & GUSTAFSSON, L.E. (1994). Ca(2+)-dependent and Ca(2+)-independent exhaled nitric oxide, presence in germ-free animals, and inhibition by arginine analogues. Eur. J. Pharmacol., 264, 13-20.
27. RICCIARDOLO, F.L.M., NADEL, J.A., YOISHlHARA, S & GEPPETTI, P. (1994). Evidence for reduction of bradykinin-induced bronchoconstriction in guinea-pigs by release of nitric oxide. Br. J. Pharmacol., 113, 1147-1152.
28. ROBBINS, R.A., BARNES. P.J., SPRINGALL, D.R., WARREN, J.B., KWON, O.J., BUTTERY, L.D., WILSON, A.J., GELLER, D.A. & POLAK, J.M. (1994), Expression of inducible nitric oxide in human lung epithelial cells. Biochem. Biophys. Res. Commun., 203, 209-218.
29. SADEGHI HASHJIN, G., FOLKERTS, G., HENRICKS, P.A., VERHEYEN, A.K., VAN DER LINDE, H.J., VAN ARK, I., COENE, A. & NIJKAMP, F.P. (1996). Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am. J. Respir. Crit. Care Med., 153, 1697-1701.
30. SANTING, R.E., HOEKSTRA, Y., PASMAN, Y., ZAAGSMA, J & MEURS, H. (1994a). The importance of eosinophil activation for the development of allergen-induced bronchial hyperreactivity in conscious, unrestrained guinea-pigs. Clin. Exp. Allergy, 24, 1157-1163.
31. SANTING, R.E., MEURS, H., VAN DER MARK, T.W., REMIE, R., OOSTEROM, W.V., BROUWER, F. & ZAAGSMA, J. (1992). A novel method to assess airway function parameters in chronically instrumented, unrestrained guinea-pigs. Pulm. Pharmacol., 5, 265-272.
32. SANTING, R.E., OLYMULDER, C.G., ZAAGSMA, J. & MEURS, H. (1994b). Relationships among allergen-induced early and late phase airway obstructions, bronchial hyperreactivity, and inflammation in conscious, unrestrained guinea pigs. J. Allergy Clin. Immunol., 93, 1021-1030.
33. SANTING, RE., PASMAN, Y., OLYMULDER, C.G., ROFFEL, A.F., MEURS, H. & ZAAGSMA, J. (1995). Contribution of a cholinergic reflex mechanism to allergen-induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea-pigs. Br. J. Pharmacol., 114, 414-418.
34. VAN AMSTERDAM, R.G., BROUWER, F. & ZAAGSMA, J. (1989), Analysis of the beta-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction. Agents Actions, 26, 48-51.
35. WALTER, R., SCHAFFNER, A. & SCHOEDON, G. (1994). Differential regulation of constitutive and inducible nitric oxide production by inflammatory stimuli in murine endothelial cells. Biochem. Biophys. Res. Commun., 202, 450-455.
36. YAN, Z.Q., HANSSON, G.K., SKOOGH, B.E. & LOTVALL, J.O. (1995). Induction of nitric oxide synthase in a model of allergic occupational asthma. Allergy, 50, 760-764.
37. YATES, D.H., KHARlTONOV, S.A., ROBBINS, R.A., THOMAS, P.S. & BARNES, P.J. (1995). Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am. J. Respir. Crit. Care Med., 152, 892-896.
38. YATES, D.H., KHARITONOV, S.A., THOMAS, P.A. & BARNES, P.J. (1996). Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med., 154, 247-250.
39. YEADON, M. & PRICE, R. (1995). Introduction of calcium-independent nitric oxide synthase by allergen challenge in sensitized rat lung in vivo. Br. J. Pharmacol., 116, 2545-2546.