[18O]-labeled singlet oxygen as a tool for mechanistic studies of 8-oxo-7,8-dihydroguanine oxidative damage: Detection of spiroiminodihydantoin, imidazolone and oxazolone derivatives

Biological Chemistry

Volumn 383, Issue 3-4, 2002, Pages 607-617

  Martinez, Glaucia R ^a   Medeiros, Marisa H G ^a   Ravanat, Jean Luc ^a   Cadet, Jean ^a   Di Mascio, Paolo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

8 oxo 7,8 dihydro 2 deoxyguanosine; 18O labeled endoperoxide; DNA damage; Mass spectrometry; Singlet oxygen; Spiroiminodihydantoin

Indexed keywords

8 HYDROXYGUANINE; BIS(2 HYDROXYPROPYL)NITROSAMINE; DNA; ENDOPEROXIDE; GUANINE; HYDANTOIN DERIVATIVE; HYDROPEROXIDE; IMIDAZOLE DERIVATIVE; NUCLEOSIDE; OXAZOLONE; OXYGEN 18; SINGLET OXYGEN; WATER; 8-HYDROXYGUANINE; DRUG DERIVATIVE; GUANOSINE; IMIDAZOLONE; METHYLENE BLUE; OXYGEN; PHOTOSENSITIZING AGENT; SPIRO COMPOUND; SPIROIMINODIHYDANTOIN;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEGRADATION KINETICS; DIASTEREOISOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SOLUBILITY; TANDEM MASS SPECTROMETRY; CHEMISTRY; CONFORMATION; ELECTROSPRAY MASS SPECTROMETRY; METHODOLOGY; PHYSIOLOGY; STEREOISOMERISM;

GUANINE; GUANOSINE; IMIDAZOLES; ISOTOPE LABELING; METHYLENE BLUE; MOLECULAR CONFORMATION; OXAZOLONE; OXIDATIVE STRESS; OXYGEN ISOTOPES; PHOTOSENSITIZING AGENTS; SINGLET OXYGEN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 0036012746     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.063     Document Type: Article

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