Synthesis of new modified DNAs by hyperthermophilic DNA polymerase: Substrate and template specificity of functionalized thymidine analogues bearing an sp3-hybridized carbon at the C5 α-position for several DNA polymerases

Bioconjugate Chemistry

Volumn 13, Issue 2, 2002, Pages 309-316

  Sawai, Hiroki ^a   Ozaki Nakamura, Akiko ^a   Mine, Masayuki ^a   Ozaki, Hiroaki ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DNA; ENZYMES; ESCHERICHIA COLI;

CARBOXYL GROUPS; DNA POLYMERASE; FUNCTIONALIZED; HYPERTHERMOPHILIC; KLENOW FRAGMENT; METHYL ESTERS; MODIFIED DNA; PRIMER EXTENSION; TRIPHOSPHATE; Α-POSITIONS;

SUBSTRATES;

ESCHERICHIA COLI; PYROCOCCUS; THERMOCOCCUS KODAKARAENSIS;

DNA; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE BETA; DRUG DERIVATIVE; NUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE; THYMIDINE;

ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA TEMPLATE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; MASS SPECTROMETRY; METABOLISM; NUCLEOTIDE SEQUENCE; PYROCOCCUS;

BASE SEQUENCE; DNA; DNA POLYMERASE I; DNA-DIRECTED DNA POLYMERASE; MOLECULAR STRUCTURE; NUCLEOTIDES; OLIGODEOXYRIBONUCLEOTIDES; PYROCOCCUS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC; THYMIDINE;

EID: 0036009644     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc010088l     Document Type: Article

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