p53 expression, growth, and spontaneous metastasis of the human GI 101 breast carcinoma in athymic nude mice

Journal of Experimental Therapeutics and Oncology

Volumn 2, Issue 2, 2002, Pages 121-127

  Daoud, Sayed S ^a   Leathers, Charles W ^b   Hurst, Josephine M ^c  

^a Departments of Pharmaceutical Sciences   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c R G Inst for Cancer Res Inc   (United States)

Author keywords

Breast cancer; GI 101 tumor cells; Immunohistochemistry; p53 oncoprotein; Spontaneous metastasis

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXILLARY LYMPH NODE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; STAINING; TUMOR EMBOLISM; TUMOR GROWTH; ANIMAL; CANCER TRANSPLANTATION; CHEMISTRY; EXPERIMENTAL NEOPLASM; LUNG TUMOR; PATHOLOGY; XENOGRAFT;

ANIMAL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NEOPLASM TRANSPLANTATION; PROTEIN P53; SUPPORT, U.S. GOV'T, P.H.S.; TRANSPLANTATION, HETEROLOGOUS; ANIMALS; HUMANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036009632     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1359-4117.2002.01018.x     Document Type: Article

References (25)

1. Cancer statistics, 2000
2. Heterotransplantation of human breast carcinoma in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene
3. Transplantation of human tumors in nude mice. JNCI
4. A novel model of a metastatic human breast tumor xenograft line
5. Antitumor effects of liposome-incorporated camptothecin in human malignant xenografts
6. An immunochemical analysis of the human nuclear phosphoprotein p53: New monoclonal antibodies and epitope mapping using recombinant p53
7. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
8. Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice
9. Behavior of tumors produced by transplantation of human mammary cell lines in athymic nude mice
10. Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
11. Why is p53 protein stabilized in neoplasia? Some answers but many more questions?
12. p53 mutation spectrum and load: The generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer
13. Regulation of p53 stability and activity in response to genotoxic stress
14. Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumors
15. p53 determination alongside classical prognostic factors in node-negative breast cancer: An evaluation at more than 10-year follow-up
16. p53 oncoprotein accumulation in adenoid cystic carcinoma of parotid and palatine salivary glands
17. Combined role of tumor angiogenesis, bcl- 2, and p53 expression in the prognosis of patients with colorectal carcinoma
18. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastoma but not in differentiated tumors
19. Cellular accumulation of p53 protein: An independent prognostic factor in stage II breast cancer
20. Nuclear p53 protein accumulates preferentially in medullary and highgrade ductal but rarely in lobular breast carcinoma
21. Correlation between the conformational phenotype of p53 and its subcellular location
22. Large E 1 B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation
23. Protein synthesis required to anchor a mutant p53 protein which is temperature sensitive for nuclear transport
24. p53 protein accumulation detected by five different antibodies: Relationship to prognosis and heat shock protein 70 in breast cancer
25. Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion