Structure and function of collagen-derived endostatin inhibitors of angiogenesis

IUBMB Life

Volumn 53, Issue 2, 2002, Pages 77-84

  Sasaki, Takako ^a   Timpl, Rupert ^a   Hohenester, Erhard ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Angiogenesis inhibitors; Cell interactions; Collagens; Heparin binding; Signal transduction; X ray structure

Indexed keywords

ANGIOGENESIS INHIBITOR; COLLAGEN DERIVATIVE; COLLAGEN TYPE 15; COLLAGEN TYPE 18; DYE; ENDOSTATIN; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG; COLLAGEN; PEPTIDE FRAGMENT;

ANGIOGENESIS; CANCER GROWTH; CANCER INHIBITION; ENDOTHELIUM CELL; HUMAN; NONHUMAN; OLIGOMERIZATION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; VASCULARIZATION;

ANIMAL; CELL DIVISION; COLLAGEN; HUMAN; MODELS, MOLECULAR; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; ANIMALS; COLLAGEN TYPE XVIII; ENDOSTATINS; HUMANS;

ANIMALIA;

EID: 0036001158     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540211466     Document Type: Review

References (54)

1. Mechanisms of angiogenesis
2. Mechanism of angiogenesis and arteriogenesis
3. Angiogenesis in cancer and other diseases
4. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
5. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
6. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
7. The role of collagen-derived proteolytic fragments in angiogenesis
8. Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes
9. Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones
10. Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts
11. Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells
12. Collagen XVIII is a basement membrane heparan sulfate proteoglycan
13. Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome)
14. Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice
15. The NCl/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance
16. Zinc-binding of endostatin is essential for its antiangiogenic activity
17. Endostatin: Yeast production, mutants and antitumor effect in renal cell carcinoma
18. Antiangiogenesis activity of restin, NC10 domain of human collagen XV: Comparison to endostatin
19. Zincligand-disrupted recombinant, human endostatin: Potent inhibition of tumor growth, safety and pharmacokinetic profile
20. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin
21. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity
22. Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc-binding
23. Secreted cathepsin L generates endostatin from collagen XVIII
24. The generation of endostatins is mediated by elastase
25. Variable zinc coordination in endostatin
26. Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen XV
27. Crystal structure of the angiogenesis inhibitor endostatin at 1.5 Å resolution
28. Zinc-dependent dimers observed in crystals of human endostatin
29. Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin
30. Cell surface glypicans are low-affinity endostatin receptors
31. Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls
32. Endostatin inhibits endothelial and tumor cellular invasions by blocking the activation and catalytic activity of matrix metalloproteinase
33. Interaction of endostatin with integrins implicated in angiogenesis
34. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
35. Endostatin binds tropomyosin. A potential modulator of the antitumor activity of endostatin
36. Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesion and actin stress fibers in cultured human endothelial cells
37. Endostatin-induced tyrosine-kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis
38. Generation and degradation of human endostatin proteins by various proteinases
39. Isolation and characterization of the circulating form of human endostatin
40. Hepatocytes as a source of collagen type XVIII endostatin
41. Mouse endostatin inhibits the formation of lung and liver metastasis
42. Antiangiogenesis signals by endostatin
43. Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain
44. Endostatin regulates branching morphogenesis of renal epithelium cells and ureteric bud
45. Endostatin induces endothelial cell apoptosis
46. Endostatin reduces vascularization, blood flow, and growth in rat gliosarcoma
47. The angiogenesis inhibitor, endostatin, does not affect murine cutaneous wound healing
48. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
49. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene
50. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy
51. Local endostatin treatment of gliomas administered by microencapsulated producer cells
52. An extensively modified version of MOLSCRIPT which includes greatly enhanced colouring facilities
53. Raster3D version 2.0. A program for photorealistic molecular graphics
54. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons