Structure and function of the Entamoeba histolytica Gal/GalNAc lectin

International Review of Cytology

Volumn 216, Issue , 2002, Pages 59-80

  Mann, Barbara J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Entamoeba histolytica; Gal GalNAc; Integrin; Lectin

Indexed keywords

DIMER; GALACTOSE; INTEGRIN; LECTIN; MONOCLONAL ANTIBODY; N ACETYLGALACTOSAMINE; PROTEIN SUBUNIT; VIRULENCE FACTOR; GALACTOSE INHIBITABLE ADHERENCE PROTEIN, ENTAMOEBA HISTOLYTICA; ISOPROTEIN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; PROTOZOAL PROTEIN;

CELL ADHESION; CELL INVASION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; CYTOLYSIS; DISULFIDE BOND; ENTAMOEBA HISTOLYTICA; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CARBOHYDRATE METABOLISM; CHEMISTRY; EPITOPE MAPPING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PATHOGENICITY; PHYSIOLOGY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA;

ACETYLGALACTOSAMINE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, SURFACE; CARBOHYDRATE METABOLISM; CELL ADHESION; ENTAMOEBA HISTOLYTICA; EPITOPE MAPPING; GALACTOSE; GENE EXPRESSION REGULATION; HUMANS; INTEGRINS; LECTINS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0036000594     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(02)16003-7     Document Type: Article

References (75)

1. High affinity binding of the Entamoeba histolytica lectin to polyvalent N-acetylgalactosaminides
2. Antisense inhibition of expression of the light subunit (35 kDa) of the Gal/GalNac lectin complex inhibits Entamoeba histolytica virulence
3. Specificity of glycosphingolipid recognition by Entamoeba histolytica trophozoites
4. Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica
5. Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica
6. Entamoeba histolytica and Entamoeba dispar: Differences in numbers and expression of cysteine proteinase genes
7. Adherence of pathogenic and non-pathogenic Entamoeba histolytica strains to neutrophils
8. Analysis of the 170-kDa lectin gene promoter of Entamoeba histolytica
9. Interaction of antibodies with Entamoeba histolytica trophozoites from experimental amebic liver abscess: An immunocytochemical study
10. 2+-regulated transcriptional repressor
11. Rat and human colonic mucins bind to and inhibit the adherence lectin of Entamoeba histolytica
12. Identification of the 150-kDa surface antigen of Entamoeba histolytica as a galactose- and N-acetyl-D-galactosamine-inhibitable lectin
13. The 150 kDa subunit of the Gal/GalNAc lectin of Entamoeba histolytica is a member of a gene family containing multiple CXXC motifs
14. Entamoeba dispar, an organism reborn
15. Entamoeba histolytica: An overview of the biology of the organism
16. Regulation of Entamoeba invadens encystation and gene expression with galactose and N-acetylglucosamine
17. The embryonic enhancer-binding protein SSAP contains a novel DNA-binding domain which has homology to several RNA-binding proteins
18. Comparison of adherence, cytotoxicity, and Gal/GalNAc lectin gene structure in Entamoeba histolytica and Entamoeba dispar
19. Infection and immunity mediated by the carbohydrate recognition domain of the Entamoeba histolytica Gal/GalNAc lectin
20. A role for a galactose lectin and its ligands during encystment of Entamoeba
21. Phosphatidylinositol glycan (PI-G) anchored membrane proteins
22. Control of ferredoxin and Gal/GalNAc lectin gene expression in Entamoeba histolytica by a cis-acting DNA sequence
23. Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs
24. Isolation and expression of the gene for a major surface protein of Giardia lamblia
25. Interaction between Entamoeba histolytica and human polymorphonuclear neutrophils
26. Comparison of PCR, isoenzyme analysis, and antigen detection for diagnosis of Entamoeba histolytica infection
27. The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1β subunit: Sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phophorylation site
28. Caspase 3-dependent killing of host cells by the parasite Entamoeba histolytica
29. Epidemiology
30. Amoebapores
31. Contact-dependent transfer of the galactose-specific lectin of Entamoeba histolytica to the lateral surface of enterocytes in culture
32. Entamoeba histolytica disturbs the tight junction complex in human enteric T84 cell layers
33. Use of Chinese hamster ovary cells with altered glycosylation patterns to define the carbohydrate specificity of Entamoeba histolytica adhesion
34. Identification of an epitope on the Entamoeba histolytica 170-kD lectin conferring antibody-mediated protection against invasive amebiasis
35. Molecular analysis of the Gal/GalNAc adhesin of Entamoeba histolytica
36. Cell surface proteins of Entamoeba histolytica
37. Sequence of the cysteine-rich heavy subunit of the galactose lectin of Entamoeba histolytica
38. Neutralizing monoclonal antibody epitopes of the Entamoeba histolytica galactose adhesin map to the cysteine-rich extracellular domain of the 170-kilodalton subunit
39. Protection in a gerbil model of amebiasis by oral immunization with Salmonella expressing the galactose N-acetyl D-galactosamine inhibitable lectin of Entamoeba histolytica
40. Structural analysis of the light subunit of the Entamoeba histolytica galactose-specific adherence lectin
41. Sequence analysis of genes encoding the light subunit of the Entamoeba histolytica galactose-specific adhesin
42. Use of monoclonal anti-light subunit antibodies to study the structure and function of the Entamoeba histolytica Gal/GalNAc adherence lectin
43. The RNP domain: A sequence-specific RNA-binding domain involved in processing and transport of RNA
44. 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeletal interaction
45. Recent advances in amebiasis
46. Isolation of the galactose-binding lectin that mediated the in vitro adherence of Entamoeba histolytica
47. Subunit structure of the galactose and N-acetyl-D-galactosamine-inhibitable adherence lectin of Entamoeba histolytica
48. Monoclonal antibodies against the galactose-binding lectin of Entamoeba histolytica enhance adherence
49. A gene homologous to hgl2 of Entamoeba histolytica is present and expressed in Entamoeba dispar
50. The cysteine-rich region of the Entamoeba histolytica adherence lectin (170-kilodalton subunit) is sufficient for high-affinity Gal/GalNAc-specific binding in vitro
51. Analysis of the gene family encoding the Entamoeba histolytica galactose-specific adhesin 170-kDa subunit
52. Upstream regulatory elements controlling expression of the Entamoeba histolytica lectin
53. Carbohydrate-binding proteins: Tertiary structures and protein-sugar interactions
54. Entamoeba histolytica: Target cells killed by trophozoites undergo DNA fragmentation which is not blocked by Bcl-2
55. Physical mapping and expression of gene families encoding the N-acetyl D-galactosamine adherence lectin of Entamoeba histolytica
56. Entamoeba histolytica: Deletion of the GPI anchor signal sequence on the Gal/GalNAc lectin light subunit prevents its assembly into the lectin heterodimer
57. Role of adherence in cytopathogenic mechanisms of Entamoeba histolytica. Study with mammalian tissue culture cells and human erythrocytes
58. Cytopathogenic mechanisms of Entamoeba histolytica
59. Effect of ion channel inhibitors on the cytopathogenicity of Entamoeba histolytica
60. Relationship of free intracellular calcium to the cytolytic activity of Entamoeba histolytica
61. Characterization of cell surface carbohydrate receptors for Entamoeba histolytica adherence lectin
62. Clinical manifestations and diagnosis
63. Activation of complement by pathogenic and nonpathogenic Entamoeba histolytica
64. Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells
65. An upstream regulatory element containing two nine basepair repeats regulates expression of the Entamoeba histolytica hg15 lectin gene
66. Identification of two Entamoeba histolytica sequence-specific URE4 enhancer-binding proteins with homology to the RNA-binding motif RRM
67. Entamoeba histolytica induces host cell death in amebic liver abscess by a non-Fas-dependent, non-tumor necrosis factor alpha-dependent pathway of apoptosis
68. Primary structure of the 170-kDa surface lectin of pathogenic Entamoeba histolytica
69. Molecular cloning of cDNA and genomic sequences coding for the 35-kilodalton subunit of the galactose-inhibitable lectin of pathogenic Entamoeba histolytica
70. Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains
71. Identification of a Gal/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium
72. 2 integrin motif
73. A DNA sequence corresponding to the gene encoding cysteine proteinase 5 in Entamoeba histolytica is present and positionally conserved but highly degenerated in Entamoeba dispar
74. Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica
75. Use of a recombinant 170-kilodalton surface antigen of Entamoeba histolytica for serodiagnosis of amebiasis and identification of immunodominant domains of the native molecule