Evaluation of [76Br]FBAU 3′,5′-dibenzoate as a lipophilic prodrug for brain imaging

Nuclear Medicine and Biology

Volumn 29, Issue 5, 2002, Pages 527-535

  Kao, Chih Hao K ^a   Waki, Atsuo ^a   Sassaman, Mark B ^a   Jagoda, Elaine M ^a   Szajek, Lawrence P ^a   Ravasi, Laura ^a,b   Shimoji, Kazuaki ^a   Eckelman, William C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Brain uptake; Bromine 76; FBAU; PET; Proliferation marker; Thymidine analogs

Indexed keywords

1 (2 FLUORO 2 DEOXY 3,5 O DIBENZOYL BETA DEXTRO ARABINOFURANOSYL) 5 BROMOURACIL BR 76; 1 (2 FLUORO 2 DEOXY BETA DEXTRO ARABINOFURANOSYL) 5 BROMOURACIL BR; TRACER; UNCLASSIFIED DRUG; 1 (2 FLUORO 2 DEOXY 3,5 O DIBENZOYLARABINOFURANOSYL) 5 BROMOURACIL; 1 (2 FLUORO 2 DEOXYARABINOFURANOSYL) 5 BROMOURACIL; 1-(2-FLUORO-2-DEOXY-3,5-O-DIBENZOYLARABINOFURANOSYL)-5-BROMOURACIL; 1-(2-FLUORO-2-DEOXYARABINOFURANOSYL)-5-BROMOURACIL; 5 BROMOURACIL; DNA; DRUG DERIVATIVE; PRODRUG; RADIOPHARMACEUTICAL AGENT;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SCREENING; DRUG STABILITY; HUMAN; HYDROLYSIS; LIPOPHILICITY; MALE; NONHUMAN; RADIOACTIVITY; RAT; ANIMAL; BRAIN; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; EVALUATION; FEMALE; METABOLISM; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; BROMOURACIL; DNA; FEMALE; HYDROLYSIS; MALE; MODELS, CHEMICAL; MODELS, MOLECULAR; PRODRUGS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 0035999170     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00324-4     Document Type: Article

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