Review article: Pathogenesis of sporadic and familial gastric cancer - Implications for clinical management and cancer prevention

Alimentary Pharmacology and Therapeutics

Volumn 16, Issue 6, 2002, Pages 1059-1066

  Ebert, M P A ^a   Malfertheiner, P ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; MICROSATELLITE DNA;

CANCER PATIENT; CANCER PREVENTION; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; EARLY DIAGNOSIS; FAMILIAL CANCER; GENETIC ANALYSIS; HUMAN; MICROBIOLOGICAL EXAMINATION; MICROSATELLITE INSTABILITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; STOMACH CANCER; CELL TRANSFORMATION; DNA DAMAGE; EPIDEMIOLOGY; GASTRECTOMY; GENETIC PREDISPOSITION; GENETICS; HELICOBACTER INFECTION; INCIDENCE; ONCOGENE; PATHOPHYSIOLOGY; PEDIGREE; PREVENTIVE MEDICINE; STOMACH TUMOR;

CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; EPIDEMIOLOGIC STUDIES; GASTRECTOMY; GENETIC PREDISPOSITION TO DISEASE; HELICOBACTER INFECTIONS; HUMAN; INCIDENCE; MICROSATELLITE REPEATS; ONCOGENES; PEDIGREE; PREVENTIVE MEDICINE; STOMACH NEOPLASMS; SUPPORT, NON-U.S. GOV'T; HUMANS;

EID: 0035999138     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2002.01288.x     Document Type: Review

References (83)

1. Gastric carcinoma
2. Helicobacter pylori in gastric lymphoma and carcinoma
3. Working group on the evaluation of carcinogenic risks to humans. Helicobacter pylori
4. Helicobacter pylori infection and gastric carcinoma in a population of Japanese-Americans in Hawaii
5. Helicobacter pylori infection and gastric cancer: Systematic review of the epidemiological studies
6. Human gastric carcinogenesis, a multistep and multifactorial process - First American cancer society award lecture on cancer epidemiology and prevention
7. Phenotypic and genotypic events in gastric carcinogenesis
8. Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review
9. Risk factors suggesting malignant transformation of gastric adenoma: Univariate and multivariate analysis
10. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
11. Microsatellite instability in the adenoma-carcinoma sequence of the stomach
12. Allelotype of the adenoma-carcinoma sequence of the stomach
13. Gegenwärtiger stand der molekularpathologie des magenkarzinoms
14. Expression of cyclin E in human gastric adenomas and adenocarcinomas: Correlation with proliferative activity and p53 status
15. Upper gastrointestinal polyps in familial adenomatous polyposis
16. Upper gastrointestinal disease in patients with familial adenomatous polyposis
17. Natural history of gastric adenomas in patients with familial adenomatosis coli/Gardner's syndrome
18. Gastric adenocarcinoma: Pathomorphology and molecular pathology
19. Molecular biological observations in gastric cancer
20. Telomerase, immortality and cancer
21. Gastric cancer with high telomerase activity shows rapid development and invasiveness
22. Upregulation of human telomerase catalytic subunit during gastric carcinogenesis
23. Amplification of c-myc, K-sam, and c-met in gastric cancers: Detection by fluorescence in situ hybridization
24. Frequency of TPR-MET rearrangement in patients with gastric carcinoma and in first-degree relatives
25. Amplification, overexpression and rearrangement of the c-erbB2 protooncogene in primary human stomach carcinomas
26. Relationship of c-erbB2 protein expression and gene amplification to invasion and metastasis in human gastric cancer
27. p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type
28. Expression of p53 in early T1 gastric carcinoma and precancerous adjacent mucosa
29. Loss of heterozygosity of APC/MCC gene in differentiated and undifferentiated gastric carcinoma in Taiwan
30. Somatic mutation of the APC gene in gastric cancer: Frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma
31. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
32. The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: More than intercellular glue?
33. Molecular organization of the uvomorulin-catenin complex
34. The cadherin superfamily at the synapse: More members, more missions
35. Cadherin cell adhesion receptors as a morphogenetic regulator
36. A novel cadherin cell adhesion molecule: Its expression patterns associated with implantation and organogenesis of mouse embryos
37. Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation
38. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas
39. Alpha-catenin expression is decreased in human gastric cancers and in the gastric mucosa of first-degree relatives
40. Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes
41. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
42. Frequent somatic mutations of the β-catenin gene in intestinal-type gastric cancer
43. Increased β-catenin mRNA levels and mutational alterations of the APC and β-catenin gene are present in intestinal-type gastric cancer
44. The role of microsatellite instability in gastric carcinoma
45. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
46. Gastric carcinomas with microsatellite instability: Clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes
47. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues
48. CpG island methylator phenotype in colorectal cancer
49. Family history and the risk of stomach and colorectal cancer
50. A relationship between cancer of the stomach and the ABO blood groups
51. Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient
52. Pernicious anemia and cancer of the stomach
53. Genetic considerations in polyps and cancer of the gastro-intestinal tract
54. Mortality from and risk of gastric carcinoma among patients with pernicious anemia
55. ABO blood groups in patients with gastric carcinoma associated with pernicious anemia
56. Distribution of ABO blood groups in patients with pernicious anemia, gastric carcinoma and gastric carcinoma associated with pernicious anemia
57. Family history and risk of stomach cancer in Italy
58. Family history and subsite of gastric cancer: Data from a case-referent study in Japan
59. Family study of gastric carcinoma: With special reference to histological types
60. Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma
61. Helicobacter pylori infection among offspring of patients with stomach cancer
62. Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients
63. Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori
64. Interleukin-1 polymorphisms associated with increased risk of gastric cancer
65. Expression of transforming growth factor beta 1 in gastric cancer and in the gastric mucosa of first degree relatives of patients with gastric cancer
66. Microsatellite instability in adenocarcinomas of the upper gastrointestinal tract: Relation to clinicopathological variables and family history
67. Current concepts in the management of Helicobacter pylori infection - The Maastricht 2-2000 consensus report
68. Familial gastric cancer: Overview and guidelines for management
69. Incidence of gastric cancer and breast cancer in CDH1 (E-Cadherin) mutation carriers from hereditary diffuse gastric cancer families
70. E-cadherin germline mutations define in inherited cancer syndrome dominated by diffuse gastric cancer
71. Identification of germline E-cadherin mutations in gastric cancer families of European origin
72. Germline E-cadherin gene mutations predispose to familial gastric cancer and colorectal cancer
73. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
74. Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome
75. An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation of TP53
76. Familial gastric cancer: Clinicopathological characteristics. RER phenotype and germline p53 and E-cadherin mutations
77. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutation
78. Germline E-cadherin gene mutations. Is prophylactic total gastrectomy indicated?
79. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer
80. Importance of early screening and prophylactic thyroidectomy in asymptomatic nonindex RET germline carriers
81. French national ad hoc committee strongly resists prophylactic mastectomy
82. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer