Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo

Antiviral Research

Volumn 55, Issue 1, 2002, Pages 179-188

  Vogel, J U ^a   Michaelis, M ^a   Neyts, J ^b   Blaheta, R A ^a   Snoeck, R ^b   Andrei, G ^b   De Clercq, E ^b   Rabenau, H F ^a   Kreuter, J ^c   Cinatl, J ^a   Doerr, H W ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Antiviral activity; Cytomegalovirus; Ethylenediaminedisuccinic acid; Immunomodulatory activity

Indexed keywords

CHELATING AGENT; CIDOFOVIR; ETHYLENEDIAMINEDISUCCINIC ACID; GANCICLOVIR; INTERCELLULAR ADHESION MOLECULE 1; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CYTOSINE; DRUG DERIVATIVE; ETHYLENEDIAMINE DERIVATIVE; IMMUNOLOGICAL ADJUVANT; N,N' ETHYLENEDIAMINE DISUCCINIC ACID; N,N'-ETHYLENEDIAMINE DISUCCINIC ACID; ORGANOPHOSPHORUS COMPOUND; PHOSPHONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL ADHESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE; ANIMAL; ANTIBIOTIC RESISTANCE; BETAHERPESVIRINAE; CELL LINE; COMPARATIVE STUDY; HERPES VIRUS INFECTION; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMAL; ANTIVIRAL AGENTS; CELL ADHESION; CELL LINE; CHELATING AGENTS; COMPARATIVE STUDY; CYTOMEGALOVIRUS; CYTOSINE; DRUG RESISTANCE, MICROBIAL; ETHYLENEDIAMINES; HERPESVIRIDAE INFECTIONS; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; JURKAT CELLS; MICE; MICE, SCID; MUROMEGALOVIRUS; ORGANOPHOSPHORUS COMPOUNDS; SUCCINATES; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION; ANIMALS; HUMANS; PHOSPHONIC ACIDS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MAIZE CHLOROTIC MOTTLE VIRUS; MOUSE CYTOMEGALOVIRUS 1; MURINAE;

EID: 0035997945     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00025-6     Document Type: Article

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