Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions

Pharmaceutical Research

Volumn 19, Issue 7, 2002, Pages 1052-1060

  Emerich, D F ^a   Snodgrass, P ^a   Lafreniere, D ^a   Dean, R L ^a   Salzberg, H ^a   Marsh, J ^a   Perdomo, B ^a   Arastu, M ^a   Winn, S R ^b   Bartus, R T ^a,c  

^a ALKERMES INC   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

5 FU; Carboplatin; Doxorubicin; Microspheres; Peripheral tumors; Sustained release

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; DOXORUBICIN; FLUOROURACIL; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; BOLUS INJECTION; CANCER GRAFT; CONTROLLED STUDY; DOSE RESPONSE; HISTOPATHOLOGY; MALE; NONHUMAN; POLYPHARMACY; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION; TUMOR GROWTH; ANIMAL; CANCER TRANSPLANTATION; CELL CULTURE; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG SCREENING; FISCHER 344 RAT; INFUSION; INTRALESIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; METHODOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSPLANTATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, PARENTERAL; INJECTIONS, INTRALESIONAL; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SUBCUTANEOUS; MALE; MICROSPHERES; NEOPLASM TRANSPLANTATION; RATS; RATS, INBRED F344; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035997342     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016434926649     Document Type: Article

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