Injectable chemotherapeutic microspheres and glioma I: Enhanced survival following implantation into the cavity wall of debulked tumors

Pharmaceutical Research

Volumn 17, Issue 7, 2000, Pages 767-775

  Emerich, D F ^a   Winn, S R ^b   Hu, Y ^a   Marsh, J ^a   Snodgrass, P ^a   LaFreniere, D ^a   Wiens, T ^a   Hasler, B P ^a   Bartus, R T ^a  

^a ALKERMES INC   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

BCNU; Carboplatin; Glioma; Microsphere; Sustained release

Indexed keywords

BIOPOLYMER; CARBOPLATIN; CARMUSTINE; MICROSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG IMPLANTATION; GLIOMA; INTERMETHOD COMPARISON; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CARBOPLATIN; CARMUSTINE; DELAYED-ACTION PREPARATIONS; GLIOMA; MALE; MICROSPHERES; POLYMERS; RATS; RATS, INBRED F344;

EID: 0033845910     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007576405039     Document Type: Article

References (30)

1. Brain tumors, part I
2. Interstitial chemotherapy of the 9L gliosarcoma: Controlled release polymers for drug delivery to the brain
3. Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma
4. Efficacy of intralesionally administered cisplatin-impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat
5. Effect of stereotactic implantation of biodegradable 5-Fluoroacil-loaded microspheres in healthy and C6 glioma-bearing rats
6. Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat
7. The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase I trial
8. Placebo-controlled trials of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas
9. Intratumoral chemotherapy
10. Assumptions in the radiotherapy of glioblastoma
11. Controlled cisplatin delivery system using poly(DL-lactic acid)
12. Preparation and characterization of 5-Fluorocil-loaded microparticles as biodegradable anticancer drug carriers
13. Local and sustained delivery of 5-Fluoracil from biodegradable microspheres for the radiosensitization of glioblastoma
14. Biocompatibility of Poly (DL-Lactide-co-Glycolide) microspheres implanted into the brain
15. Enhanced delivery of carboplatin into brain tumors with intraveneous Cereport (RMP-7): Dramatic differences and insight ganed from dosing parameters
16. A new coupling component for sulfanilamide determination
17. Colorimetric method for the determination of 1,3-bis(2-chloroethyl)-1-nitrosourea
18. Intravenous Cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels and enhances survival
19. The antitumor agent, 1,3-bis(2-chloroethyl)-1-nitrosourea
20. Interstitial chemotherapy of experimental brain tumors: Comparison of intratumoral injection versus polymeric controlled release
21. Distribution of drugs following controlled delivery to the brain interstitium
22. Distribution of macromolecular dyes in brain using positive pressure infusion: A model for direct controlled delivery of therapeutic agents
23. Millimeter-scale positoning of a nerve-growth-factor source and biological activity in the brain
24. Bulk flow of interstitial fluid after intracranial injection of blue dextran 200
25. Interstitial fluid flow along white matter tracts: A potentially important mechanism for the dissemination of primary brain tumors
26. Signals that go with the flow
27. Computerized tomographic and pathologic studies of untreated, quiescent, and recurrent glioblastoma multiforme
28. Brain tumor invasion: Clinical patterns of malignant astrocytoma spread
29. Dissemination of high grade astrocytomas along white matter tracts: Observations and therapeutic implications