Upregulation of estrogen and androgen receptors modulate expression of FGF-2 and FGF-7 in human, cultured, prostatic stromal cells exposed to high concentrations of estradiol

Prostate Cancer and Prostatic Diseases

Volumn 5, Issue 2, 2002, Pages 105-110

  Smith, P ^a   Rhodes, N P ^a   Ke, Y ^a   Foster, C S ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Benign hyperplasia; Estrogen receptors; Fibroblast growth factor; Keratinocyte growth factor; Prostate stroma; Tissue culture

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR; RECEPTOR ANTIBODY; SEX HORMONE; STEROID; TESTOSTERONE; FGF7 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR;

ARTICLE; CELL GROWTH; CELL ISOLATION; CELL LABELING; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; CULTURE MEDIUM; EXPOSURE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSTATE; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; REPRODUCIBILITY; STROMA CELL; BIOSYNTHESIS; CULTURE TECHNIQUE; CYTOLOGY; GENE EXPRESSION REGULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; UPREGULATION;

ESTRADIOL; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; MALE; PROSTATE; PROSTATIC HYPERPLASIA; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; SUPPORT, NON-U.S. GOV'T; TISSUE CULTURE; UP-REGULATION; CULTURE TECHNIQUES; FIBROBLAST GROWTH FACTOR 7; HUMANS;

EID: 0035996415     PISSN: 13657852     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500571     Document Type: Article

References (30)

1. Rationale for using aromatase inhibitors to manage benign prostatic hyperplasia. Experimental studies
2. Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol and estrone in epithelium and stroma of normal and hyperplastic human prostate
3. The pathogenesis of benign prostatic hyperplasia
4. Clinical and experimental studies of benign prostatic hyperplasia
5. Androgen and estrogen receptor content in spontaneous and experimentally induced canine prostatic hyperplasia
6. Hormonal regulation of the androgen receptor expression in human prostatic cells in culture
7. Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: Oestrogen regulation of the androgen receptor
8. Expression of estrogen receptor in diseased human prostate assessed by non-radioactive in situ hybridization and immunohistochemistry
9. Estrogen receptor messenger RNA in human benign prostatic hyperplasia: Detection, localization and modulation with a long-acting gonadotrophin-releasing hormone agonist
10. Elevated estrogen receptor expression in human prostatic stromal cells by androgen ablation therapy
11. Peptide growth factors in the prostate as mediators of stromal epithelial interaction
12. Prostate stroma: Physiology
13. Role of peptide growth factors in the prostate-a review
14. Modulating effect of estrogen and testosterone on prostatic stromal cell phenotype differentiation induced by nor-adrenaline and doxazosin
15. Differential expression of acidic- and basic fibroblast growth factors in benign prostatic hyperplasia identified by immunohistochemistry
16. Expression of basic fibroblast growth factor and its receptors FGF R1 and FGF R2 in human benign prostatic hyperplasia treated with finasteride
17. Basic fibroblast growth factor. A potential mediator of stromal growth in the human prostate
18. Benign prostatic stromal cells are regulated by basic fibroblast growth factor and transforming growth factor-beta 1
19. Expression of fibroblast growth factors (FGFs) and FGF receptors in human prostate
20. Keratinocyte growth factor expression in hormone insensitive prostate cancer
21. Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions and growth factors
22. Estrogen receptors in the human male prostatic urethra and prostate in prostatic cancer and benign prostatic hyperplasia
23. Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats
24. Immunolocalisation of oestrogen receptor beta in human tissues
25. Prostatic stromal cell phenotype is directly modulated by norepinephrine
26. Benign prostatic hyperplasia and normal prostate aging: Differences in types 1 and II 5 alpha-reductase and steroid hormone receptor messenger ribonucleic acid (mRNA) levels, but not in insulin-like growth factor mRNA levels
27. Experience with low-dose oestrogen in the treatment of advanced prostate cancer: A personal view
28. From estrogen to androgen receptor: A new pathway for sex hormones in prostate
29. Immunolocalization of the keratinocyte growth factor in benign and neoplastic human prostate and its relation to androgen receptor
30. Stem cells in prostatic epithelia