Expression of basic fibroblast growth factor and its receptors FGFR1 and FGFR2 in human prostatic hyperplasia treated benign with finasteride

Prostate

Volumn 40, Issue 2, 1999, Pages 83-88

  Sáez, Carmen ^a   González Baena, Antonio C ^a   Japón, Miguel A ^a   Giráldez, Javier ^a   Segura, Dolores I ^a   Rodríguez Vallejo, José M ^b   González Esteban, Jorge ^b   Miranda, Gonzalo ^a   Torrubia, Francisco ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

Benign prostatic hyperplasia; bFGF; FGF receptors; Finasteride

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; FINASTERIDE;

ADULT; AGED; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; FINASTERIDE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE; PROSTATIC HYPERPLASIA; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0344780832     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19990701)40:2<83::AID-PROS3>3.0.CO;2-N     Document Type: Article

References (28)

1. Steiner MS. Review of peptide growth factors in benign prostatic hyperplasia and urological malignancy. J Urol 1995;153: 1085-1096.
2. Culig Z, Hobish A, Cronauer MV, Radmayr C, Hittmair A, Zhang J, Thurnher M, Bartsch G, Klocker H. Regulation of prostatic growth and function by peptide growth factors. Prostate 1996;28:392-405.
3. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. Structural characterization and biological functions of fibroblast growth factor. Endocr Rev 1987;8:95-114.
4. Nishi N, Matuo Y, Muguruma Y, Yoshitake Y, Nishikawa K, Wada F. A human prostatic growth factor (hPGF) partial purification and characterization. Biochem Biophys Res Commun 1985;132:1103-1109.
5. Story M, Livingstone B, Baeten L, Swartz S, Jacobs S, Begun F, Lawson R. Cultured human prostate-derived fibroblasts produce a factor that stimulates their growth with properties indistinguishable from basic fibroblast growth factor. Prostate 1989; 15:355-365.
6. Ittman M, Mansukhani A. Expression of fibroblast growth factors (FGFs) and FGF receptors in human prostate. J Urol 1997; 157:351-356.
7. Nishi N, Matuo Y, Kunitomi K, Takenaka I, Usami M, Kotake T, Wada F. Comparative analysis of growth factors in normal and pathologic human prostates. Prostate 1988;13:39-48.
8. Mori H, Maki M, Oishi K, Jaye M, Igarahi K, Yoshida O, Hatanaka M. Increased expression of genes for basic fibroblast growth factor and transforming growth factor type β2 in human benign prostatic hyperplasia. Prostate 1990;16:71-80.
9. Begun FP, Story MT, Hopp KA, Shapiro E, Lawson RK. Regional concentration of basic fibroblast growth factor in normal and benign hyperplastic human prostates. J Urol 1995;153:839-843.
10. Johnson D, Williams L. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993;60:1-41.
11. Story M, Hopp KA, Molter M, Meier D. Characteristics of FGF-receptors expressed by stromal and epithelial cells cultured from normal and hyperplastic prostates. Growth Factors 1994;10;269-280.
12. Hamaguchi A, Toomaya I, Yoshiki T, Kimura H. Demonstration of fibroblast growth factor receptor-1 in human prostate by polymerase chain reaction and immunohistochemistry. Prostate 1995;27:141-147.
13. Katz AE, Benson MC, Wise GJ, Olsson CA, Bandyk, MG, Sawczuk IS, Tomashefsky P, Buttyan R. Gene activity during the early phase of androgen-stimulated rat prostate regrowth. Cancer Res 1989;49:5889-5894.
14. Geller J, Sionit LR, Baird A, Kohls M, Connors KM, Hoffman RM. In vivo and in vitro effects of androgen on fibroblast growth factor-2 concentrations in the human prostate. Prostate 1994;25:206-209.
15. Geller J. Effect of finasteride, a 5α-reductase inhibitor on prostate tissue androgens and prostate-specific antigen. J Clin Endocrinol Metab 1990;71:1552-1555.
16. McConnell JD, Wilson JD, George FW, Geller J, Pappas F, Stoner E. Finasteride, an inhibitor of 5α-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab 1992;74:505-508.
17. Stoner E, Finasteride Study Group. Three year safety and efficiency data on the use of finasteride in the treatment of benign prostatic hyperplasia. Urology 1994;43:284-294.
18. Finasteride Study Group. Finasteride (MK-906) in the treatment of benign prostatic hyperplasia. Prostate 1993;22:291-299.
19. Boyle P, Gould L, Roehrborn CG. Prostate volume predicts outcome of treatment of benign prostatic hyperplasia with finasteride: meta-analysis of randomized clinical trials. Urology 1996; 48:398-405.
20. Sáez C, González-Baena AC, Japón MA, Giráldez J, Segura DI, Miranda G, Rodríguez-Vallejo JM, González-Esteban J, Torrubia F. Regressive changes in finasteride-treated human hyperplastic prostates correlate with an upregulation of TGF-β receptor expression. Prostate 1998;37:84-90.
21. Muller WJ, Lee FS, Dickson C, Peters G, Pattengale P, Leder P. The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J 1990;9:907-913.
22. Sherwood ER, Fong CJ, Lee C, Kozlowski JM. Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate. Endocrinology 1992;130:2955-2963.
23. Peehl DM, Stamey TA, Rubin JS. Fibroblast growth factor can replace epidermal growth factor for clonal proliferation of human prostate epithelial cells. J Urol [Suppl] 1991;145:311.
24. Mydlo J, Michaeli J, Heston W, Fair W. Expression of basic fibroblastic growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma. Prostate 1988;13:241-247.
25. Rittsmaster RS, Norman RW, Thomas LN, Rowden G. Evidence for atrophy and apoptosis in the prostates of men given finasteride. J Clin Endocrinol Metab 1996;81:814-819.
26. Yoshimura K, Kaji H, Kamidono S, Chihara K. Expression of basic fibroblast growth factor (FGF-2) messenger ribonucleic acid is regulated by testosterone in the rat anterior pituitary. Growth Factors 1994;10:253-258.
27. Nishi N, Oya H, Matsumoto K, Nakamura K, Miyanaka H, Wada F. Changes in gene expression of growth factors and their receptors during castration-induced involution and androgen-induced regrowth of rat prostates. Prostate 1996;28:139-152.
28. Saric T, Shain SA. Androgen regulation of prostate cancer cell FGF-1, FGF-2, and FGF-8: preferential down-regulation of FGF-2 transcripts. Growth Factors 1998;16:69-87.