Deoxycholic acid conjugates are muscarinic cholinergic receptor antagonists

Pharmacology

Volumn 65, Issue 4, 2002, Pages 215-221

  Raufman, Jean Pierre ^a   Chen, Ying ^a   Zimniak, Piotr ^a   Cheng, Kunrong ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Acetylcholine; Bile acids; Chinese hamster ovary cells; Muscarinic receptors

Indexed keywords

ACETYLCHOLINE; ANTIBIOTIC G 418; BILE ACID; CARBACHOL; CHOLINESTERASE; DEOXYCHOLIC ACID; GLYCINE; INOSITOL PHOSPHATE; LACTATE DEHYDROGENASE; METHYLSCOPOLAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; RADIOLIGAND; TAURINE; TRYPAN BLUE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; MUSCARINIC RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHINA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HAMSTER; IC 50; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; PHOSPHORYLATION; RADIOASSAY; RAT;

ANIMAL; BILE ACIDS AND SALTS; CELL MEMBRANE; CHO CELLS; CHOLINERGIC AGONISTS; CHOLINESTERASES; COMPARATIVE STUDY; DEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLYCINE; HAMSTERS; HUMAN; INOSITOL PHOSPHATES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCARINIC ANTAGONISTS; PHOSPHORYLATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, MUSCARINIC; SUPPORT, U.S. GOV'T, NON-P.H.S.; TAURINE; ANIMALS; CRICETINAE; HUMANS; RECEPTOR, MUSCARINIC M3;

EID: 0035996234     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064347     Document Type: Article

References (15)

1. Lithocholyltaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach
2. Muscarinic acetylcholine receptor subtypes: Localization and structure/function
3. Identification of a family of muscarinic acetylcholine receptor genes
4. The muscarinic receptor gene expressed in rabbit parietal cells is the m3 subtype
5. Characterization of cholinergic receptors mediating pepsinogen secretion from chief cells
6. Sulfation of lithocholyltaurine alters the affinity of the molecule for muscarinic receptor subtypes
7. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3
8. Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation
9. Cationanion gap and choleretic properties of rat bile
10. Hepatic extraction of bile salts in conscious dogs
11. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules
12. Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid-regulated ductal secretion
13. Identification of a nuclear receptor for bile acids
14. Bile acids: Natural ligands for an orphan nuclear receptor
15. Ligand: A versatile computerized approach for characterization of ligand-binding systems