The sensitivity of MCF10A breast epithelial cells to alkylating drugs is enhanced by the inhibition of O6-methylguanine-DNA methyltransferase transcription with a synthetic double strand DNA oligonucleotide

Breast Cancer Research and Treatment

Volumn 73, Issue 3, 2002, Pages 207-213

  Mariani, Laura ^a   Piccirilli, Antonella ^a   Citti, Lorenzo ^a   Colombo, Maria Giovanna ^a   Poliseno, Laura ^a   Rainaldi, Giuseppe ^a  

^a CNR   (Italy)

Author keywords

cis acting oligonucleotide; Drug sensitivity; MGMT; Transcriptional activation

Indexed keywords

ALKYLATING AGENT; CHLORMETHINE DERIVATIVE; DNA; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MITOZOLOMIDE; OLIGONUCLEOTIDE; DOUBLE STRANDED DNA;

ARTICLE; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; DNA DAMAGE; DNA REPAIR; DRUG SCREENING; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; PATHOLOGY; BREAST EPITHELIUM; CONTROLLED STUDY; DNA ALKYLATION; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENHANCER REGION; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONTENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, ALKYLATING; BREAST NEOPLASMS; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; NITROGEN MUSTARD COMPOUNDS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGONUCLEOTIDES; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; HUMAN;

EID: 0035992533     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015808205169     Document Type: Article

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