Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture

Journal of Biomedical Science

Volumn 9, Issue 2, 2002, Pages 133-139

  Zhang, Mingjie ^a   Li, Xingxiang ^a   Pang, Xiaowu ^a   Ding, Linna ^a   Wood, Owen ^a   Clouse, Kathleen A ^a   Hewlett, Indira ^a   Dayton, Andrew I ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Apoptosis; Bcl 2; HIV; HIV 1BAL; Macrophage; Tat

Indexed keywords

MESSENGER RNA; PROTEIN BCL 2; TRANSACTIVATOR PROTEIN; PEPTIDE FRAGMENT;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL LEVEL; CELL PROTECTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; CULTURE TECHNIQUE; DRUG EFFECT; GENETICS; METABOLISM; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

APOPTOSIS; CELL CULTURE TECHNIQUES; GENE PRODUCTS, TAT; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER;

EID: 0035991882     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000048209     Document Type: Article

References (55)

1. Identification of a novel domain of HIV Tat involved in monocyte chemotaxis
2. Cell dysfunction depletion in AIDS: The programmed cell death hypothesis
3. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes
4. Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/caspase-8
5. Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HIV-infected monocytes
6. Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection
7. Caspases: Conductors of the cell death machinery in lymphoma cells
8. The expression of Fas ligand by macrophages and its upregulation by human immunodeficiency virus infection
9. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients
10. Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection
11. Bcl-2 family members and the mitochondria in apoptosis
12. Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes
13. Tat protein induces human immunodeficiency virus type 1 (HIV-1) co-receptors and promotes infection with both macrophagetropic and T-lymphotropic HIV-1 strains
14. Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?
15. Multifaceted activities of the HIV-1 transactivator of transcription, Tat
16. Perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation
17. HIV type 1 Tat protein enhances activation but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals
18. Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages
19. Monocytic differentiation modulates apoptotic response to cytotoxic anti-Fas antibody and tumor necrosis factor in human monoblast U937 cells
20. A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis
21. A mechanism for HIV pathogenesis
22. HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes
23. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
24. Resistance of bone marrow-derived macrophages to apoptosis is associated with the expression of X-linked inhibitor of apoptosis protein in primary cultures of bone marrow cells
25. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, bad, or caspase activation
26. Dual role of HIV Tat in regulation of apoptosis in T cells
27. Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID mice
28. Macrophage-tropic HIV: Critical for AIDS pathogenesis?
29. Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates
30. Activation-induced apoptosis in human macrophages: Developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon γ
31. Recombinant human immunodeficiency virus type 1 genomes with Tat unconstrained by overlapping reading frames reveal residues in tat important for replication in tissue culture
32. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-κB factors
33. Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: A possible mechanism of bystander cell death in HIV infection
34. Accelerated apoptosis in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals
35. Macrophages require constitutive NF-κB activation to maintain A1 expression and mitochondrial homeostasis
36. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors
37. FLICE-inhibitory protein expression during macrophage differentiation confers resistance to Fas-mediated apoptosis
38. Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2
39. HIV type 1 Tat protein induces apoptosis and death in Jurkat cells
40. Immunopathogenic mechanisms of HIV infection
41. Expression of human immunodeficiency virus type I tat results in down-regulation of Bcl-2 and induction of apoptosis in hematopoietic cells
42. The role of c-FLIP in modulation of CD95-induced apoptosis
43. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
44. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
45. Cellular and viral determinants that regulate HIV-1 infection in macrophages
46. The fight of viruses against apoptosis
47. Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein
48. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
49. Decreased ability of HIV-1 tat protein-treated accessory cells to organize cellular clusters is associated with partial activation of T cells
50. Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1
51. The human immunodeficiency virus type-1 (HIV-1) Tat protein and Bcl-2 gene expression
52. The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells
53. Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes
54. Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis
55. Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: Upregulation of TRAIL in primary human macrophages by HIV-1 Tat