Effects of early dexamethasone therapy on pulmonary fibrogenic mediators and respiratory mechanics in preterm infants

European Cytokine Network

Volumn 13, Issue 2, 2002, Pages 207-214

  Vento, Giovanni ^a   Matassa, Piero G ^a   Ameglio, Franco ^a   Capoluongo, Ettore ^a   Tortorolo, Luca ^a   Romagnoli, Costantino ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

BFGF; Dexamethasone; Pulmonary function testing; TGF 1; Tracheobronchial aspirate fluid; VEGF

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CORTICOSTEROID; CYTOKINE; DEXAMETHASONE; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; ANTIINFLAMMATORY AGENT;

ARTICLE; CHRONIC LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FEMALE; FIBRIN FORMATION; HUMAN; IMMUNOMODULATION; INFANT; INTUBATION; LUNG ASPIRATION; LUNG FUNCTION TEST; LUNG MECHANICS; MALE; PREMATURITY; BLOOD; BREATHING MECHANICS; DRUG EFFECT; GESTATIONAL AGE; LOW BIRTH WEIGHT; LUNG FIBROSIS; MULTICENTER STUDY; NEWBORN; PHYSIOLOGY;

ANTI-INFLAMMATORY AGENTS, STEROIDAL; CYTOKINES; DEXAMETHASONE; GESTATIONAL AGE; HUMAN; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; PULMONARY FIBROSIS; RESPIRATORY MECHANICS; ANTI-INFLAMMATORY AGENTS; HUMANS;

EID: 0035991508     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. The role of inflammation in the pathogenesis of bronchopulmonary dysplasia
2. Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity
3. Decreased alveolarization in baboon survivors with bronchopulmonary dysplasia
4. Bronchopulmonary dysplasia-pathology
5. Transforming growth factor-β in tissue fibrosis
6. Transforming growth factor-β increases mRNA for matrix proteins both in the presence and absence of changes in mRNA stability
7. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension
8. Heparin-binding angiogenic factors (basic fibroblast growth factor and vascular endothelial growth factor) in early neonatal life
9. Vascular endothelial growth factor is expressed in ovine pulmonary vascular smooth muscle cells in vitro and regulated by hypoxia and dexamethasone
10. Fibrosis of the lung and other tissues: New concepts in pathogenesis and treatment
11. Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: Effect of age and postnatal dexamethasone
12. Promoter competitors as novel antifibrotics that inhibit transforming growth factor-beta induction of collagen and noncollagen protein synthesis in fibroblasts
13. Transforming growth factor-beta 1 modulates the expression of vascular endothelial growth factor by osteoblasts
14. Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: A randomised, controlled trial
15. Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia
16. A scoring system to predict the evolution of respiratory distress syndrome into chronic lung disease in preterm infants
17. High total antioxidant activity and uric acid in tracheobronchial aspirate fluid of preterm infants during oxidative stress: An adaptive response to hyperoxia?
18. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
19. Effects of aerosolized interferon-alpha in patients with pulmonary tuberculosis
20. Relative likelihood of bronchopulmonary dysplasia based on pulmonary mechanics measured in preterm neonates during the first week of life
21. Increased incidence of sighs (augmented inspiratory efforts) during synchronized intermittent mandatory ventilation (SIMV) in preterm neonates
22. Influence of chest wall distortion on esophageal pressure
23. Linear modeling of ventilatory mechanics during spontaneous breathing
24. Nonlinear pressure/volume relationship and measurements of lung mechanics in infants
25. Bronchopulmonary dysplasia: Clinical presentation
26. The changing pattern of chronic lung disease of prematurity
27. Different patterns of pulmonary sequelae after hyaline membrane disease: Heterogeneity of bronchopulmonary dysplasia? A clinicopathologic study
28. Early postnatal (< 96 hours) corticosteroids for preventing chronic lung disease in preterm infants
29. Early postnatal dexamethasone for the prevention of chronic lung disease in high-risk preterm infants
30. A multicenter trial of two dexamethasone regimens in ventilator-dependent premature infants
31. Effect on growth of two different dexamethasone courses for preterm infants at risk of chronic lung disease. A randomized trial
32. Early postnatal dexamethasone therapy for the prevention of chronic lung disease in preterm infants with respiratory distress syndrome: A multicenter clinical trial
33. Early dexamethasone therapy and very low birth weight infants
34. Long-term selective down-regulation of brain glucocorticoid receptors after neonatal dexamethasone treatment in rats
35. Randomized placebo-controlled trial of a 42 day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants; outcome of study participants at 1 year adjusted age
36. Vascular endothelial growth factor in human preterm lung
37. Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation
38. The role of pulmonary macrophages in chronic lung disease of early infancy
39. On the detection of neutrophil-derived vascular endothelial growth factor (VEGF)
40. Streptococcus pneumoniae induces secretion of vascular endothelial growth factor by human neutrophils
41. Mechanism of transforming growth factor-beta-1-induced expression of vascular endothelial growth factor in murine osteoblastic MC3T3-E1 cells
42. Concentration of vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta-1) in the serum of patients with cervical cancer: Prediction of response
43. Growth factors VEGF and TGF-beta-1 in peritoneal dialysis
44. Two distinct signalling pathways are involved in FGF2-stimulated proliferation of choriocapillary endothelial cells: A comparative study with VEGF
45. Downregulatory cytokines in tracheobronchial aspirate fluid from infants with chronic lung disease of prematurity
46. Mediators of fetal inflammation in extremely low gestational age newborns
47. Early changes in respiratory compliance and resistance during the development of bronchopulmonary dysplasia in the era of surfactant therapy