Effects of aerosolized interferon-α in patients with pulmonary tuberculosis

American Journal of Respiratory and Critical Care Medicine

Volumn 158, Issue 4, 1998, Pages 1156-1162

  Giosuè, Sandro ^a   Casarini, Massimo ^b   Alemanno, Lucilla ^b   Galluccio, Gianni ^b   Mattia, Paolo ^b   Pedicelli, Gioacchino ^b   Rebek, Lionello ^b   Bisetti, Alberto ^b   Ameglio, Franco ^b  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIMYCOBACTERIAL AGENT;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; DRUG SAFETY; FEMALE; FEVER; HUMAN; LUNG TUBERCULOSIS; MALE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; SPUTUM ANALYSIS;

EID: 0031796534     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.158.4.9803065     Document Type: Article

References (35)

1. Murray, C. J. L., K. Styblo, and A. Rouillon. 1990. Tuberculosis in developing countries: burden, intervention and cost. Bull. Int. Union Tuberc. Lung Dis. 65:6-26.
2. Edwards, D., and C. H. Kirkpatric. 1986. The immunology of mycobacterial diseases. Am. Rev. Respir. Dis. 134:1062-1071.
3. + T cells. J. Exp. Med. 178:1655-1663.
4. Cacciarelli, T. V., O. M. Martinez, R. G. Gish, J. C. Villanueva, and S. M. Krams. 1996. Immunoregulatory cytokines in chronic hepatitis C virus infection: pre- and posttreatment with Interferon-alpha. Hepatology 24:6-9.
5. Crossley, A. R., A. M. Dickinson, S. J. Proctor, and J. E. Calvert. 1996. Effects of Interferon alpha therapy on immune parameters in immune thrombocytopenic purpura. Autoimmunity 24:81-100.
6. Romagnani, S. 1992. Induction of Th1 and Th2 responses: a key role for the "naturalimmune response? Immunol. Today 13:379-381.
7. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1199-1204.
8. Parronchi, P., M. De Carli, R. Manetti, C. Simonelli, S. Sampognaro, M. P. Piccinni, D. Macchia, E. Maggi, G. Del Prete, and S. Romagnani. 1992. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 149:2977-2983.
9. Merrit, J. A., E. C. Borden, and L. A. Ball. 1985. Measurement of 2′-5′ oligoadenylate syntelase in patients receiving interferon-α. J. Interferon Res. 5:191-198.
10. Giosuè, S., M. Casarini, F. Ameglio, L. Alemanno, C. Saltini, and A. Bisetti. 1996. Minimal dose of aerosolized interferon-α in human subjects: biological consequences and side-effects. Eur. Respir. J. 9:42-46.
11. Miorner, H., N. Gebre, U. Karlsson, G. Jonsson, R. Macaden, A. Wolde, and A. Assefa. 1994. Diagnosis of pulmonary tuberculosis. Lancet 344:127.
12. Remy-Jardin, M., F. Giraud, J. Remy, L. Wattinne, B. Wallaert, and A. Duhamel. 1994. Pulmonary sarcoidosis: role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment. Radiology 191:675-680.
13. Task Group on BAL. 1989. Technical recommendation and guidelines for bronchoalveolar lavage (BAL): report of the SEP. Eur. Respir. J. 2:561-585.
14. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin, and R. G. Crystal. 1986. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol. 60:532-538.
15. American Thoracic Society. 1986. Treatment of tuberculosis and tuberculosis infection in adults and children. Am. Rev. Respir. Dis. 134:355-363.
16. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon-γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
17. Munoz-Fernandez, M. A., M. A. Fernandez, and M. Fresno. 1992. Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 22:301-307.
18. Taha, R. A., T. C. Kotsimbos, Y. L. Song, D. Menzies, and O. Hamid. 1997. IFN-γ and IL-12 are increased in active compared with inactive tuberculosis. Am. J. Respir. Crit. Care Med. 155:1135-1139.
19. Gutterman, J. U. 1994. Cytokine therapeutics: lessons from interferon alpha. Proc. Natl. Acad. Sci. U.S.A. 91:1198-1205.
20. Condos, R., W. N. Rom, and N. W. Schluger. 1997. Treatment of multi-drug-resistant pulmonary tuberculosis with interferon-gamma via aerosol. Lancet 149:1513-1515.
21. Belardelli, F., and I. Gresser. 1996. The neglected role of type 1 interferon in the T-cell response: implications for its clinical use. Immunol. Today 17:369-372.
22. Tzung, S. P., T. C. Mahl, P. Lance, V. Andersen, and S. A. Cohen. 1992. Interferon-α prevents endotoxin-induced mortality in mice. Eur. J. Immunol. 22:3097-3101.
23. Belardelli, F. 1995. Role of interferons and other cytokines in the regulation of the immune response. APMIS 103:161-179.
24. + T cells in active pulmonary tuberculosis. Chest 111:606-611.
25. Zhang, M., Y. Lin, D. V. Iyer, J. Gong, J. S. Abrams, and P. F. Barnes. 1995. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun. 63:3231-3234.
26. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
27. Hoheisel, G. B., L. Tabak, H. Teschler, F. Erkan, C. Kroegel, and U. Costabel. 1994. Bronchoalveolar lavage cytology and immonocytology in pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 149: 460-463.
28. Bermudez, L. E. M., P. Stevens, P. Kolonoski, M. Wu, and L. S. Young. 1989. Treatment of experimental disseminated Mycobacterium avium complex infection in mice with recombinant IL-2 and tumor necrosis factor. J. Immunol. 143:2996-3000.
29. Im, J. G., H. Itoh, Y. S. Shim, J. H. Lee, J. Ahn, M. C. Han, and S. Noma. 1993. Pulmonary tuberculosis: CT findings in early active disease and sequential change with antituberculous therapy. Radiology 186:653-660.
30. Webb, W. R., N. L. Muller, and D. P. Naidich. 1996. High-Resolution CT of the Lung, 2nd ed. Raven Press, New York. 173-185.
31. Callard, R., and A. Gearing. 1994. The Cytokine Facts Book, 1st ed. Academic Press, London. 18-27.
32. Law, K., M. Weiden, T. Harkin, K. Tchou-Wong, C. Chi, and W. N. Rom. 1996. Increased release of interleukin-1β, interleukin-6, and tumor necrosis factor-α by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 153: 799-804.
33. McCrea, K. A., J. E. Ensor, K. Nall, E. R. Bleecker, and J. D. Hasday. 1994. Altered cytokine regulation in the lungs of cigarette smokers. Am. J. Respir. Crit Care Med. 150:696-703.
34. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J. C. Virchow. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
35. Prior, C. and P L. Haslam. 1989. Interferon in lungs [letter]. Lancet 10:1333.